Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
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High expression of Endogenous Retroviruses from intrauterine life to adulthood in two mouse models of Autism Spectrum Disorders.
Chiara Cipriani,Laura Ricceri,Claudia Matteucci,Alessia De Felice,Anna Maria Tartaglione,Ayele Argaw-Denboba,Francesca Pica,Sandro Grelli,Gemma Calamandrei,Paola Sinibaldi Vallebona,Paola Sinibaldi Vallebona,Emanuela Balestrieri +11 more
TL;DR: Results are in agreement with previous findings in ASD children, supporting the hypothesis that ERVs may serve as biomarkers of atypical brain development and the changes in ERVs and proinflammatory cytokines expression could be related with the autistic-like traits acquisition in the two mouse models.
Journal ArticleDOI
Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders.
TL;DR: Current efforts to understand how altered peripheral sensory neuron dysfunction may impact brain development and complex behaviors in ASD models are described and whether targeting peripheral somatosensory neurons to improve their function might also improve related ASD phenotypes.
Journal ArticleDOI
Embryonic Exposure to Valproic Acid Affects Social Predispositions for Dynamic Cues of Animate Motion in Newly-Hatched Chicks.
Elena Lorenzi,Alessandra Pross,Orsola Rosa-Salva,Elisabetta Versace,Elisabetta Versace,Paola Sgadò,Giorgio Vallortigara +6 more
TL;DR: Early predispositions are a potentially useful tool to detect early ASD symptoms in human neonates and to investigate the molecular and neurobiological mechanisms underlying the onset of this neurodevelopmental disorder.
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Alleviation of N-Methyl-d-Aspartate Receptor-Dependent Long-Term Depression via Regulation of the Glycogen Synthase Kinase-3β Pathway in the Amygdala of a Valproic Acid-Induced Animal Model of Autism
TL;DR: The results suggested that NMDA receptor-related synaptic plasticity is dysfunctional in VPA-exposed offspring and GSK-3β in the amygdala is critical for synaptic Plasticity at the glutamatergic synapses and is related to social behavior.
Journal ArticleDOI
Early Behavioral Alterations and Increased Expression of Endogenous Retroviruses Are Inherited Across Generations in Mice Prenatally Exposed to Valproic Acid.
Anna Maria Tartaglione,Chiara Cipriani,Flavia Chiarotti,Benedetta Perrone,Emanuela Balestrieri,Claudia Matteucci,Paola Sinibaldi-Vallebona,Paola Sinibaldi-Vallebona,Gemma Calamandrei,Laura Ricceri +9 more
TL;DR: Evaluated the transgenerational impact of prenatal VPA exposure on mouse early behavioral development, studying F1, F2, and F3 generations after VPA challenge on gestational day 10.5 to suggest ERVs as possible downstream effectors of the VPA epigenetic alterations.
References
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Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
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Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
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Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.