Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
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Journal ArticleDOI
The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
Roman M. Stilling,Marcel van de Wouw,Gerard Clarke,Catherine Stanton,Timothy G. Dinan,John F. Cryan +5 more
TL;DR: A critical review of the literature on butyrate and its effects on multiple aspects of host physiology with a focus on brain function and behaviour is provided and it is hypothesised that butyrates and other volatile SCFAs produced by microbes may be involved in regulating the impact of the microbiome on behaviour including social communication.
Journal ArticleDOI
The bowel and beyond: the enteric nervous system in neurological disorders
Meenakshi Rao,Michael D. Gershon +1 more
TL;DR: Evidence for ENS dysfunction is reviewed in the aetiopathogenesis of autism spectrum disorder, amyotrophic lateral sclerosis, transmissible spongiform encephalopathies, Parkinson disease and Alzheimer disease, and animal models suggest that common pathophysiological mechanisms account for the frequency of gastrointestinal comorbidity in these conditions.
Journal ArticleDOI
Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Caroline G M de Theije,Harm Wopereis,Mohamed Ramadan,Tiemen van Eijndthoven,Jolanda Lambert,Jan Knol,Johan Garssen,Aletta D. Kraneveld,Raish Oozeer +8 more
TL;DR: Findings show that autism-like behaviour and its intestinal phenotype is associated with altered microbial colonization and activity in a murine model for ASD, with preponderance in male offspring, which open new avenues in the scientific trajectory of managing neurodevelopmental disorders by gut microbiome modulation.
Journal ArticleDOI
The valproic acid-induced rodent model of autism.
TL;DR: The VPA model provides a valuable tool to investigate the neurobiology underlying autistic behavior and to screen for novel therapeutics, highlighting its importance and reliability as an environmentally-induced animal model of autism.
Journal ArticleDOI
Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.
William Mandy,Meng-Chuan Lai +1 more
TL;DR: Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene-environment interplay, and longitudinal studies to elucidate how rGE plays out over time.
References
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Journal ArticleDOI
Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies.
TL;DR: The findings indicate that disruption of early facial nerve development is involved in the etiology of asymmetric facial palsy, and may suggest a link to the Etiology of autism.
Journal ArticleDOI
Early valproic acid exposure alters functional organization in the primary visual cortex
TL;DR: It is indicated that Val exposure during a brief period of development disrupts cortical processing of sensory information at a later age and suggest a neurobiological substrate for some types of sensory deficits in fetal anticonvulsant syndrome.
Book ChapterDOI
Antiepileptic treatment in pregnant women: morphological and behavioural effects.
Torbjörn Tomson,Dina Battino +1 more
TL;DR: It is well established that children exposed to antiepileptic drugs (AEDs) in utero have an increased risk of adverse pregnancy outcomes including foetal growth retardation, major congenital malformations and impaired postnatal cognitive development.
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Affect of Seizures during Gestation on Pregnancy Outcomes in Women with Epilepsy
TL;DR: Preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes is suggested.
Journal ArticleDOI
Valproate poses risk to unborn child.
TL;DR: This study identifies VPA as a drug carrying potential risks for developmental delay and cognitive impairment and is the first to suggest that frequent tonic-clonic seizures in pregnancy have a similar effect.