Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
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The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
Roman M. Stilling,Marcel van de Wouw,Gerard Clarke,Catherine Stanton,Timothy G. Dinan,John F. Cryan +5 more
TL;DR: A critical review of the literature on butyrate and its effects on multiple aspects of host physiology with a focus on brain function and behaviour is provided and it is hypothesised that butyrates and other volatile SCFAs produced by microbes may be involved in regulating the impact of the microbiome on behaviour including social communication.
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The bowel and beyond: the enteric nervous system in neurological disorders
Meenakshi Rao,Michael D. Gershon +1 more
TL;DR: Evidence for ENS dysfunction is reviewed in the aetiopathogenesis of autism spectrum disorder, amyotrophic lateral sclerosis, transmissible spongiform encephalopathies, Parkinson disease and Alzheimer disease, and animal models suggest that common pathophysiological mechanisms account for the frequency of gastrointestinal comorbidity in these conditions.
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Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Caroline G M de Theije,Harm Wopereis,Mohamed Ramadan,Tiemen van Eijndthoven,Jolanda Lambert,Jan Knol,Johan Garssen,Aletta D. Kraneveld,Raish Oozeer +8 more
TL;DR: Findings show that autism-like behaviour and its intestinal phenotype is associated with altered microbial colonization and activity in a murine model for ASD, with preponderance in male offspring, which open new avenues in the scientific trajectory of managing neurodevelopmental disorders by gut microbiome modulation.
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The valproic acid-induced rodent model of autism.
TL;DR: The VPA model provides a valuable tool to investigate the neurobiology underlying autistic behavior and to screen for novel therapeutics, highlighting its importance and reliability as an environmentally-induced animal model of autism.
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Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.
William Mandy,Meng-Chuan Lai +1 more
TL;DR: Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene-environment interplay, and longitudinal studies to elucidate how rGE plays out over time.
References
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Journal ArticleDOI
Autism Spectrum Disorders in the Stockholm Youth Cohort: Design, Prevalence and Validity
Selma Idring,Dheeraj Rai,Henrik Dal,Christina Dalman,Harald Sturm,Eric Zander,Eric Zander,Brian K. Lee,Eva Serlachius,Cecilia Magnusson +9 more
TL;DR: The design of a large intergenerational resource for ASD research is presented, along with population-based prevalence estimates of ASD and their diagnostic validity, and findings accords with recently reported prevalence estimates from Western countries at around 1.
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Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism.
TL;DR: The results suggest that postnatal environmental manipulations can counteract the behavioral alterations in VPA rats, and propose environmental enrichment as an important tool for the treatment of autism spectrum disorders.
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Autism spectrum disorders following in utero exposure to antiepileptic drugs.
TL;DR: In utero exposure to teratogenic substances such as thalidomide and alcohol may increase the risk of developing autism spectrum disorder (ASD) and that prenatal development may be a critical time is investigated.
Journal Article
[Pharmacodynamic properties of N-dipropylacetic acid].
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Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid.
Shunsuke Kataoka,Kazuhiro Takuma,Yuta Hara,Yuko Maeda,Yukio Ago,Toshio Matsuda,Toshio Matsuda +6 more
TL;DR: It is suggested that VPA-induced histone hyperacetylation plays a key role in cortical pathology and abnormal autism-like behaviours in mice.