Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
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Book ChapterDOI
Epigenetic mechanisms in autism spectrum disorder.
TL;DR: Progress on studies designed to provide a better understanding of how epigenetic mechanisms impact transcriptional programs operative in the brain that contribute to ASD are reviewed.
Journal ArticleDOI
Zinc as a therapy in a rat model of autism prenatally induced by valproic acid.
Luana Carvalho Cezar,Thiago Berti Kirsten,Caio Cesar Navarrete da Fonseca,Ana Paula Lima,Maria Martha Bernardi,Luciano Freitas Felício +5 more
TL;DR: Prenatal VPA decreased ultrasonic vocalization, induced repetitive/restricted behaviors and cognitive inflexibility, impaired socialization, and reduced striatal TH levels compared with control group, suggesting that Zn‐induced behavioral improvement in autistic rats may not depend on TH activity.
Journal ArticleDOI
Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism.
Yuta Hara,Yukio Ago,Atsuki Taruta,Keisuke Katashiba,Shigeru Hasebe,Erika Takano,Yusuke Onaka,Hitoshi Hashimoto,Hitoshi Hashimoto,Toshio Matsuda,Kazuhiro Takuma +10 more
TL;DR: It is suggested that chronic treatment with methylphenidate or atomoxetine improves abnormal behaviors and diminishes the reduction in spine density in VPA‐treated mice via a prefrontal dopaminergic system‐dependent mechanism.
Journal ArticleDOI
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.
Roohi Mirza,Bhupesh Sharma +1 more
TL;DR: Treatment with fenofibrate significantly attenuated prenatal VPA-induced social impairment, repetitive behavior, hyperactivity, anxiety, and low exploratory activity and it may be concluded that fen ofibrate may provide neurobehavioral and biochemical benefits in prenatal Vpa-induced autism phenotypes in rats.
Journal ArticleDOI
Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System.
Ana C. Liberman,Emiliano Trias,Luana da Silva Chagas,Pablo Trindade,Marissol Dos Santos Pereira,Marissol Dos Santos Pereira,Damian Refojo,Cecilia Hedin-Pereira,Cecilia Hedin-Pereira,Cecilia Hedin-Pereira,Claudio Alberto Serfaty +10 more
TL;DR: This review discusses the ability of the early developing brain to respond to a focal lesion with a rapid compensatory plasticity of intact axons and the role of microglial activation and proinflammatory cytokines in brain repair and the involvement of neuroinflammatory conditions that alter neuroimmune interactions in four different pathologies.
References
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Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.