Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
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The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
Roman M. Stilling,Marcel van de Wouw,Gerard Clarke,Catherine Stanton,Timothy G. Dinan,John F. Cryan +5 more
TL;DR: A critical review of the literature on butyrate and its effects on multiple aspects of host physiology with a focus on brain function and behaviour is provided and it is hypothesised that butyrates and other volatile SCFAs produced by microbes may be involved in regulating the impact of the microbiome on behaviour including social communication.
Journal ArticleDOI
The bowel and beyond: the enteric nervous system in neurological disorders
Meenakshi Rao,Michael D. Gershon +1 more
TL;DR: Evidence for ENS dysfunction is reviewed in the aetiopathogenesis of autism spectrum disorder, amyotrophic lateral sclerosis, transmissible spongiform encephalopathies, Parkinson disease and Alzheimer disease, and animal models suggest that common pathophysiological mechanisms account for the frequency of gastrointestinal comorbidity in these conditions.
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Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Caroline G M de Theije,Harm Wopereis,Mohamed Ramadan,Tiemen van Eijndthoven,Jolanda Lambert,Jan Knol,Johan Garssen,Aletta D. Kraneveld,Raish Oozeer +8 more
TL;DR: Findings show that autism-like behaviour and its intestinal phenotype is associated with altered microbial colonization and activity in a murine model for ASD, with preponderance in male offspring, which open new avenues in the scientific trajectory of managing neurodevelopmental disorders by gut microbiome modulation.
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The valproic acid-induced rodent model of autism.
TL;DR: The VPA model provides a valuable tool to investigate the neurobiology underlying autistic behavior and to screen for novel therapeutics, highlighting its importance and reliability as an environmentally-induced animal model of autism.
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Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.
William Mandy,Meng-Chuan Lai +1 more
TL;DR: Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene-environment interplay, and longitudinal studies to elucidate how rGE plays out over time.
References
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Journal ArticleDOI
Foetal Antiepileptic Drug Exposure and Verbal versus Non-Verbal Abilities at Three Years of Age.
Kimford J. Meador,Gus A. Baker,Nancy Browning,Morris J. Cohen,Jill Clayton-Smith,Laura A. Kalayjian,Andres M. Kanner,Joyce Liporace,Page B. Pennell,Michael Privitera,David W. Loring +10 more
TL;DR: A dose-dependent relationship is present for both lower verbal and non-verbal abilities with valproate and for lower verbal abilities with carbamazepine and preconceptional folate may improve cognitive outcomes.
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Affect of Seizures During Gestation on Pregnancy Outcomes in Women With Epilepsy
TL;DR: Preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes is suggested.
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Child development following in utero exposure Levetiracetam vs sodium valproate
TL;DR: Children exposed to LEV in utero are not at an increased risk of delayed early cognitive development under the age of 24 months and LEV may be a preferable drug choice, where appropriate, for WWE prior to and of childbearing age.
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Risk factors for autism: translating genomic discoveries into diagnostics
TL;DR: The scientific, ethical, policy and communication aspects of translating the new discoveries into clinical and diagnostic tools for promoting the well-being of individuals and families with ASDs are discussed.
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Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation.
Zoya Marinova,Ming Ren,Jens R. Wendland,Yan Leng,Min-Huei Liang,Shigeru Yasuda,Peter Leeds,De-Maw Chuang +7 more
TL;DR: The data suggest that the phosphatidylinositol 3‐kinase/Akt pathway and Sp1 are likely involved in HSP70 induction by HDAC inhibitors, and induction of H SP70 by VPA in cortical neurons may contribute to its neuroprotective and therapeutic effects.