Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
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Patent
A chromone derivative as a dopamine d3 receptor antagonist for its use for the treatment of autism spectrum disorder
TL;DR: In this article, a chromone derivative and pharmaceutical compositions and combinations comprising a least the said derivative, which is a dopamine D3 receptor antagonist, for their use for the treatment of autism spectrum disorder are presented.
Dissertation
Etudes des mécanismes à l'origine de l'excès de garçons dans la déficience intellectuelle et les troubles du spectre autistique
TL;DR: La deficience intellectuelle (DI) and les troubles du spectre autistique (ASD) sont deux troubles neurodeveloppementaux (NDD) presentant de nombreux chevauchements genetiques et phenotypiques ainsi qu’un biais de sexe important, avec plus de garcons atteints (1,4x plus pour la DI and 4x plus for l'ASD).
Journal ArticleDOI
Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism
Chiharu Tsuji,Kazumi Furuhara,Ryuko Mizutani,Kana Minami,Pin-I Fu,Jing Zhong,Haruhiro Higashida,Shigeru Yokoyama,Takahiro Tsuji +8 more
TL;DR: In this paper , the behavioral deficit on postnatal day 5 of the F2 generation was examined to assess the onset of ASD symptoms and the locomotive activity with or without littermates was altered in F2 VPA pups.
Journal ArticleDOI
A Twin Study of Altered White Matter Heritability in Youth With Autism Spectrum Disorder.
John P. Hegarty,J C Monterrey,Qiyuan Tian,Sue C. Cleveland,Jennifer M. Phillips,Olga N. Wolke,Jennifer A. McNab,Joachim Hallmayer,Allan L. Reiss,Antonio Y. Hardan,Laura C. Lazzeroni +10 more
TL;DR: In this article , the authors examined the impact of genetic and environmental factors on white matter microstructure in twins with ASD compared to control twins without ASD, and developed a new version of the twin-pair difference score analysis method that estimates the contribution of genetic/environment factors to shared covariance between different brain and behavioral traits.
References
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Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.