Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
Reads0
Chats0
TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
More filters
Journal ArticleDOI
Environmental Enrichment Intervention in Animal Models of Autism
TL;DR: Generally, environmental enrichment results in less anxiety-like behavior, reduces repetitive behavior and the deficits in social and cognitive behaviors, and appears to be an effective model for non-pharmacological intervention in autism therapy.
Posted ContentDOI
Embryonic Exposure to Valproic Acid Disrupts Social Predispositions in Newly-Hatched Chicks
TL;DR: This work modeled ASD behavioral deficit in newborn chicks, using embryonic exposure to valproic acid (VPA), the histone deacetylases (HDACs) inhibitor that in humans is associated with an increased risk for developing ASD.
Journal ArticleDOI
Study on the Action of Chia Seed Oil in Rats' Model of Autism
TL;DR: In this article , the effect of chia seed oil (CSO) on autistic traits in offspring rats induced with valproic acid (VPA) was investigated, and it was deduced that CSO has antioxidant and neuroprotective effects which can provide good protection for autism.
Book ChapterDOI
Ketogenic Diet, Social Behavior, and Autism
TL;DR: This article reviewed the recent evidence regarding use of the ketogenic diet in the treatment of autism, especially with respect to socialization functions, and discussed the future directions for this line of research.
References
More filters
Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.