Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
Reads0
Chats0
TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
More filters
Posted ContentDOI
Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention
Satoshi Watanabe,Tohru Kurotani,Tomofumi Oga,Jun Noguchi,Risa Isoda,Akiko Nakagami,Kazuhisa Sakai,Keiko Nakagaki,Kayo Sumida,Kohei Hoshino,Koichi Saito,Izuru Miyawaki,Masayuki Sekiguchi,Keiji Wada,Takafumi Minamimoto,Noritaka Ichinohe +15 more
TL;DR: Assessment of altered cortical synapses and gene expression in the ASD model marmoset found that early synaptic phenotypes and altered gene expressions could be novel targets of efficient therapy from a young age.
Sensory Filtering and Cognitive Function in a Valproic Acid Rat Model of Autism
De Silva,Theshani A +1 more
TL;DR: This chapter discusses sensory processing theories, animal models of Autism, and the proposed framework, which aims to address these issues in more detail.
DissertationDOI
Wnt signaling regulates neuronal migration in the cerebral cortex
TL;DR: It is demonstrated that transient down-regulation of canonical Wnt signaling is necessary during the multipolar-to-bipolar transition and is of special interest for intracortical network formation.
Journal ArticleDOI
Reinforced behavioral variability in the valproate rat model of autism spectrum disorder.
Ann Galizio,Amy L. Odum +1 more
TL;DR: Testing VPA and control rats in a reinforced-behavioral-variability operant task found that VPA rats behaved slightly more variably than controls during baseline and yoked conditions, when variability was not required.
Journal ArticleDOI
Perineuronal Nets in the Dorsomedial Striatum Contribute to Behavioral Dysfunction in Mouse Models of Excessive Repetitive Behavior
TL;DR: In this paper , perineuronal nets (PNNs) are degraded in the dorsomedial striatum (DMS) using the enzyme chondroitinase ABC and assessed dendritic spine density, electrophysiology and repetitive behavior.
References
More filters
Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.