Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
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The Neuroprotective Role of Acorus calamus in Developmental and Histopathological Changes in Autism-Induced Wistar Rats
TL;DR: Assessment of the effects of Acorus calamus on developmental and histopathological changes in autism-induced Wistar rats found that it protects rat pups’ brain morphology against autism pathology in the early postnatal period.
Journal ArticleDOI
A Genome-Wide SNP Investigation of Chemical Intolerance
TL;DR: In this paper , the association between Chemical Intolerance (CI) and single nucleotide polymorphisms (SNPs) was obtained using SOLAR (Sequential Oligogenic Linkage Analysis Routines).
Journal ArticleDOI
Ameliorating age-dependent effects of resveratrol on VPA-induced social impairments and anxiety-like behaviors in a rat model of Neurodevelopmental Disorder.
Seyyed Sajjad Vakili Shahrbabaki,Amirhossein Moslemizadeh,Sedigheh Amiresmaili,Sara Sheibani Tezerji,Kobra Bahrampour Juybari,Gholamreza Sepehri,Manzumeh Shamsi Meymandi,Hamideh Bashiri +7 more
TL;DR: In this paper , the effect of resveratrol (RSV) on anxiety-like behaviors and social interaction in juvenile and adult rats of both sex in a valproic acid (VPA)-induced autistic-like model was investigated.
Book ChapterDOI
Neurobehavioral Comorbidities of Epilepsy: Lessons from Animal Models
TL;DR: It is suggested that systemic approach, rather than more commonly used isolated approach, offers more clinical-relevant and complete description of multifactorial systems that underlie neurobehavioral comorbidities of epilepsy.
Journal ArticleDOI
Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats.
Ayako Furugen,Yuki Kanno,Nanami Ohyama,Yuko Kurosawa,Naoko Jinno,Katsuya Narumi,Ken Iseki,Masaki Kobayashi +7 more
TL;DR: Findings indicate that administration of VPA alters the placental gene expression of folate carriers and metabolism-related enzymes in the rat placenta at both mid and late gestation periods.
References
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Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.