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In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
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Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period
TL;DR: The data indicate that exposing rats to methylphenidate during the preweanling period differentially affects anxiety-like behavior depending on the type of anxiety-provoking stimulus.
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A blueprint for research on Shankopathies: A view from research on autism spectrum disorder
TL;DR: A blueprint for near and longer‐term goals for fundamental and translational research on Shankopathies is proposed, with special emphasis on highly penetrant genetic disorders including Shankopathie.
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Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model
Merih Cetinkaya,Mehmet Cansev,Ferhat Cekmez,Cuneyt Tayman,Fuat Emre Canpolat,Ilker Mustafa Kafa,Esra Orenlili Yaylagul,Boris W. Kramer,Serdar Umit Sarici +8 more
TL;DR: It is shown for the first time that VPA treatment ameliorates lung damage in a neonatal rat model of hyperoxic lung injury and the preventive effect of VPA involves HDAC inhibition.
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Prenatal exposure to valproic acid alters the development of excitability in the postnatal rat hippocampus.
TL;DR: It is suggested that prenatal VPA exposure accelerates the development of hippocampal excitability before eye opening and can be used as a novel approach for the evaluation of developmental neurotoxicity.
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Valproic acid interactions with the NavMs voltage-gated sodium channel
Geancarlo Zanatta,Altin Sula,Andrew Miles,Leo C. T. Ng,Rubben Torella,David C. Pryde,Paul G. DeCaen,Bonnie A. Wallace +7 more
TL;DR: Biophysical, electrophysiological, and computational methods have been used to demonstrate that valproic acid binds to the voltage sensor region of sodium channels, at a site distinct from that in the pore domain where hydrophobicant sodium channel-targeting drugs bind, and that it does, indeed, affect channel functioning.
References
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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
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Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
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Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.