Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
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The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
Roman M. Stilling,Marcel van de Wouw,Gerard Clarke,Catherine Stanton,Timothy G. Dinan,John F. Cryan +5 more
TL;DR: A critical review of the literature on butyrate and its effects on multiple aspects of host physiology with a focus on brain function and behaviour is provided and it is hypothesised that butyrates and other volatile SCFAs produced by microbes may be involved in regulating the impact of the microbiome on behaviour including social communication.
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The bowel and beyond: the enteric nervous system in neurological disorders
Meenakshi Rao,Michael D. Gershon +1 more
TL;DR: Evidence for ENS dysfunction is reviewed in the aetiopathogenesis of autism spectrum disorder, amyotrophic lateral sclerosis, transmissible spongiform encephalopathies, Parkinson disease and Alzheimer disease, and animal models suggest that common pathophysiological mechanisms account for the frequency of gastrointestinal comorbidity in these conditions.
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Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Caroline G M de Theije,Harm Wopereis,Mohamed Ramadan,Tiemen van Eijndthoven,Jolanda Lambert,Jan Knol,Johan Garssen,Aletta D. Kraneveld,Raish Oozeer +8 more
TL;DR: Findings show that autism-like behaviour and its intestinal phenotype is associated with altered microbial colonization and activity in a murine model for ASD, with preponderance in male offspring, which open new avenues in the scientific trajectory of managing neurodevelopmental disorders by gut microbiome modulation.
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The valproic acid-induced rodent model of autism.
TL;DR: The VPA model provides a valuable tool to investigate the neurobiology underlying autistic behavior and to screen for novel therapeutics, highlighting its importance and reliability as an environmentally-induced animal model of autism.
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Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.
William Mandy,Meng-Chuan Lai +1 more
TL;DR: Future investigations should consider the specificity of risks for ASC versus other atypical neurodevelopmental trajectories, timing of risk and protective mechanisms, animal model systems to study mechanisms underlying gene-environment interplay, and longitudinal studies to elucidate how rGE plays out over time.
References
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Journal ArticleDOI
Linking etiologies in humans and animal models: studies of autism
TL;DR: Rats with motor neuron deficits also had cerebellar anomalies like those reported in studies of autistic cases, supporting the idea that these animals may be a useful model of the developmental injury that initiates autism.
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A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate.
TL;DR: Mice exposed in utero to sodium valproate demonstrate behavioral and neuroanatomical abnormalities similar to those seen in autism, the neurodevelopmental effects of this antiepileptic agent were examined in mice following its pre- or postnatal administration.
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Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society.
Cynthia L. Harden,Cynthia L. Harden,Kimford J. Meador,Page B. Pennell,W. Allen Hauser,Gary S. Gronseth,Jacqueline A. French,Samuel Wiebe,David J. Thurman,Barbara S. Koppel,Peter W. Kaplan,Julian N. Robinson,Jennifer L. Hopp,Tricia Y. Ting,Barry E. Gidal,Collin A. Hovinga,Andrew Wilner,Blanca Vazquez,Lewis B. Holmes,Allan Krumholz,Richard H. Finnell,Deborah Hirtz,Claire L. Le Guen +22 more
TL;DR: A committee assembled by the AAN reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including antiepileptic drug (AED) teratogenicity and adverse perinatal outcomes.
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Epidemiological trends in rates of autism.
TL;DR: An update of a previous review of 23 surveys of autism and PDDs has identified 32 studies published in English language journals from 1966 to 2001 that followed a two-phase design for case identification, finding that large numbers of children just failed to meet criteria for autistic disorder.
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Autism spectrum disorders and epigenetics.
TL;DR: Data reviewed in this article highlight a variety of situations in which epigenetic dysregulation is associated with the development of ASD, thereby supporting a role for epigenetics in the multifactorial etiologies of ASD.