Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
Reads0
Chats0
TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
More filters
Journal ArticleDOI
Thyroid hormone elicits intergenerational epigenetic effects on adult social behavior and fetal brain expression of autism susceptibility genes
TL;DR: For example, this article found that the brain of F2 generation E13.5 fetuses exhibited abnormal expression of genes associated with autism in humans, including Auts2, Disc1, Ldlr, Per2, Shank3, Oxtr, Igf1, Foxg1, Cd38, Grid2, Nrxn3, and Reln.
Posted ContentDOI
Valproic acid induces p19Arf-mediated cellular senescence to cause neurodevelopmental defects
Muriel Rhinn,Zapata-Bodalo I,Annabelle Klein,Jean-Luc Plassat,Tania Knauer-Meyer,William M. Keyes +5 more
TL;DR: In this article, the authors used embryonic mice and human organoids to model key features of drug exposure, including exencephaly, microcephaly and spinal defects, and found that induction of cellular senescence in neuroepithelial cells is a core feature.
Perineuronal nets in the dorsomedial striatum contribute to behavioral dysfunction in mouse models of excessive repetitive behavior
Vladislav A. Chistyakov,Brandy A. Briones,Miah N. Pitcher,Weston Fleming,Alexandra Libby,Emma J. Diethorn,Amanda E. Haye,Camden J. MacDowell,Anna D. Zych,Renee C. Waters,Timothy J. Buschman,Ilana B. Witten,Elizabeth Gould +12 more
TL;DR: In this article, perineuronal nets (PNNs) are degraded in the dorsomedial striatum (DMS) using the enzyme chondroitinase ABC and assessed dendritic spine density, electrophysiology and repetitive behavior.
Book ChapterDOI
Adverse Effects of Drugs on the Fetal Nervous System
TL;DR: This chapter describes neurological disorders affecting the fetus associated with the use of medicines and exposure to recreational substances during the pregnancy and the pathomechanisms of these drug-induced neurological disorders involving the fetus and the infant are discussed.
References
More filters
Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.