Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Anna Maria Ranzoni,Andrea Tangherloni,Andrea Tangherloni,Andrea Tangherloni,Ivan Berest,Simone Giovanni Riva,Simone Giovanni Riva,Simone Giovanni Riva,Brynelle Myers,Paulina M. Strzelecka,Jiarui Xu,Jiarui Xu,Jiarui Xu,Elisa Panada,Elisa Panada,Irina Mohorianu,Judith B. Zaugg,Ana Cvejic,Ana Cvejic,Ana Cvejic +19 more
TLDR
In this paper, the authors applied single-cell RNA sequencing (scRNA-seq) and single cell assay for transposase-accessible chromatin sequencing to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow.About:
This article is published in Cell Stem Cell.The article was published on 2021-03-04 and is currently open access. It has received 122 citations till now. The article focuses on the topics: ATAC-seq & Chromatin.read more
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FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer.
Ming Han,Fei Li,Yehan Zhang,Pengfei Dai,Juan He,Yunguang Li,Yiqin Zhu,Junke Zheng,Hai Huang,Fan Bai,Dong Gao +10 more
TL;DR: In this paper , the authors investigated the dynamics of cellular heterogeneity, transcriptome regulation, and microenvironmental factors in 107,201 cells from genetically engineered mouse prostate cancer samples with complete time series of tumor evolution seen in patients.
Journal ArticleDOI
Drosophila as a Model to Study Cellular Communication Between the Hematopoietic Niche and Blood Progenitors Under Homeostatic Conditions and in Response to an Immune Stress.
TL;DR: In this review, Drosophila cellular and molecular mechanisms involved in the communication between the niche and hematopoietic progenitors, both under homeostatic and stress conditions are summarized and similarities between mechanisms by which niches regulate hematopolietic stem/progenitor cells in Drosophile and mammals are discussed.
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Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis.
Zhaofeng Zheng,Hanqing He,Xinyu Thomas Tang,Han Zhang,Fanglin Gou,Huashan Yang,Jiaxuan Cao,Shujuan Shi,Zining Yang,Guohuan Sun,Xiaowei S. Xie,Yang Zeng,Aiqing Wen,Yu Lan,Jiaxi Zhou,Bing Liu,Bo O. Zhou,Tao Cheng,Hui Cheng +18 more
TL;DR: In this paper , a single-cell transcriptomic landscape of human fetal BM and spleen is constructed and functional HSCs were detected in the spleen by 14 PCWs.
Journal ArticleDOI
Single-Cell Analysis Using Machine Learning Techniques and Its Application to Medical Research
Ken Asada,Ken Takasawa,Hidenori Machino,Satoshi Takahashi,Norio Shinkai,Amina Bolatkan,Kazuma Kobayashi,Masaaki Komatsu,Syuzo Kaneko,Koji Okamoto,Ryuji Hamamoto +10 more
TL;DR: In this paper, the authors present a comprehensive introduction to the implementation of machine learning techniques in medical research for single-cell analysis, and discuss their usefulness and future potential for singlecell analysis.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this article , the authors discussed the recent findings and computational methods used to unravel the new hematopoietic stem cells (HSC) model revised over the classical model, which is one of the most unique, adaptive and comprehensive developmental systems on which various other body systems relies on.
References
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