Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Anna Maria Ranzoni,Andrea Tangherloni,Andrea Tangherloni,Andrea Tangherloni,Ivan Berest,Simone Giovanni Riva,Simone Giovanni Riva,Simone Giovanni Riva,Brynelle Myers,Paulina M. Strzelecka,Jiarui Xu,Jiarui Xu,Jiarui Xu,Elisa Panada,Elisa Panada,Irina Mohorianu,Judith B. Zaugg,Ana Cvejic,Ana Cvejic,Ana Cvejic +19 more
TLDR
In this paper, the authors applied single-cell RNA sequencing (scRNA-seq) and single cell assay for transposase-accessible chromatin sequencing to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow.About:
This article is published in Cell Stem Cell.The article was published on 2021-03-04 and is currently open access. It has received 122 citations till now. The article focuses on the topics: ATAC-seq & Chromatin.read more
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Multidimensional profiling reveals GATA1-modulated stage-specific chromatin states and functional associations during human erythropoiesis
TL;DR: In this article , the authors analyzed the chromatin landscape at multiple levels in defined populations from primary human erythroid culture and revealed mechanistic insights underlying chromatin rearrangements during development.
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Analysis of single-cell RNA sequencing data based on autoencoders
Andrea Tangherloni,Federico Ricciuti,Daniela Besozzi,Pietro Liò,Ana Cvejic,Ana Cvejic,Ana Cvejic +6 more
TL;DR: In this paper, the authors introduce scAEspy, a unifying tool that embodies four of the most advanced autoencoders, two novel AEs that were developed on purpose, and different loss functions.
Journal ArticleDOI
Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR
Jake R. Thomas,Anna Appios,Emily Calderbank,Nagisa Yoshida,Xiaohui Zhao,Russell S. Hamilton,Ashley Moffett,Andrew M. Sharkey,Elisa Laurenti,Courtney W. Hanna,Naomi McGovern +10 more
TL;DR: This article identified a population of placental erythro-myeloid progenitors (PEMPs) in the early human placenta that have conserved features of primitive yolk sac EMPs, including the lack of HLF expression.
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Tipping-point analysis uncovers critical transition signals from gene expression profiles
Xinan Yang,Zhezhen Wang,Andrew S. Goldstein,Yuxi Sun,Megan Rowton,Yanqiu Wang,Dannie Griggs,Ivan P. Moskowitz,John M. Cunningham +8 more
TL;DR: BioTIP as mentioned in this paper identifies tipping points and their significant gene signals, which can be applied to understanding of disease and developmental, but also to data at the cellular or organismal level.
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