Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Anna Maria Ranzoni,Andrea Tangherloni,Andrea Tangherloni,Andrea Tangherloni,Ivan Berest,Simone Giovanni Riva,Simone Giovanni Riva,Simone Giovanni Riva,Brynelle Myers,Paulina M. Strzelecka,Jiarui Xu,Jiarui Xu,Jiarui Xu,Elisa Panada,Elisa Panada,Irina Mohorianu,Judith B. Zaugg,Ana Cvejic,Ana Cvejic,Ana Cvejic +19 more
TLDR
In this paper, the authors applied single-cell RNA sequencing (scRNA-seq) and single cell assay for transposase-accessible chromatin sequencing to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow.About:
This article is published in Cell Stem Cell.The article was published on 2021-03-04 and is currently open access. It has received 122 citations till now. The article focuses on the topics: ATAC-seq & Chromatin.read more
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Genome-Wide Analysis of Yeast Metabolic Cycle through Metabolic Network Models Reveals Superiority of Integrated ATAC-seq Data over RNA-seq Data
TL;DR: The preliminary results showed that epigenomic data sets can pave the way for more accurate metabolic simulations, and it is proposed that the incorporation of epigenetic information is a promising approach in the accurate prediction of metabolic dynamics.
Journal ArticleDOI
Modeling genetic platelet disorders with human pluripotent stem cells: mega-progress but wanting more on our plate(let).
TL;DR: In this article, the authors reviewed recent advances in PSC-derived megakaryocyte (iMK) technology, focusing on platform validation, disease modeling and current limitations, and confirmed that iMK can recapitulate many transcriptional and functional aspects of megakocyte and platelet biology, including variables associated with complex genetic traits such as sex and race.
Journal ArticleDOI
Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos
Xi Dai,Honglian Shao,Nianqin Sun,Baiquan Ci,Jun Wu,Chuanyu Liu,Liang Wu,Yue Yuan,Xiaoyu Wei,Huanming Yang,Longqi Liu,Weizhi Ji,Bing Bai,Zhouchun Shang,Tao Tan +14 more
TL;DR: In this article , a single-cell assay for transposase accessible chromatin sequencing was applied to in vitro cultured cynomolgus monkey (Macaca fascicularis, hereafter referred to as monkey) embryos to investigate the chromatin status.
Posted ContentDOI
Pathway Analysis Through Mutual Information
Gustavo S. Jeuken,Lukas Käll +1 more
TL;DR: This work proposes a new method for pathway analysis, MIPath, that relies on information theoretical principles, and therefore is absent of a model for the nature of the association between pathway activity and phenotype, resulting on a very minimal set of assumptions.
Journal ArticleDOI
Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line
TL;DR: In this paper , the authors measured activity patterns across 24,844 human lymphoblastoid single cells and found that the majority of enhancers associated with the same gene display significant correlation in their chromatin profiles.
References
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