Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Anna Maria Ranzoni,Andrea Tangherloni,Andrea Tangherloni,Andrea Tangherloni,Ivan Berest,Simone Giovanni Riva,Simone Giovanni Riva,Simone Giovanni Riva,Brynelle Myers,Paulina M. Strzelecka,Jiarui Xu,Jiarui Xu,Jiarui Xu,Elisa Panada,Elisa Panada,Irina Mohorianu,Judith B. Zaugg,Ana Cvejic,Ana Cvejic,Ana Cvejic +19 more
TLDR
In this paper, the authors applied single-cell RNA sequencing (scRNA-seq) and single cell assay for transposase-accessible chromatin sequencing to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow.About:
This article is published in Cell Stem Cell.The article was published on 2021-03-04 and is currently open access. It has received 122 citations till now. The article focuses on the topics: ATAC-seq & Chromatin.read more
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Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic Hierarchy
Mikael Sommarin,Parashar Dhapola,Fatemeh Safi,Rebecca Warfvinge,Geironson Ulfsson L,Eva Erlandsson,Konturek-Ciesla A,Krishna Thakur R,Charlotta Böiers,David Bryder,Göran Karlsson +10 more
TL;DR: In this article, a pseudotime ordering of both mRNA and chromatin data revealed a bifurcation of megakaryocyte/erythroid and lympho/myeloid trajectories immediately downstream a subpopulation with an HSC-specific enhancer signature.
Journal ArticleDOI
Single-cell sortChIC identifies hierarchical chromatin dynamics during hematopoiesis
Peter Zeller,Jake Yeung,Helena Viñas Gaza,Buys de Barbanson,Vivek Bhardwaj,Marian Florescu,Reinier van der Linden,Alexander van Oudenaarden +7 more
TL;DR: In this paper , the authors developed sort-assisted single-cell chromatin immunocleavage (sortChIC) and map active and repressive histone modifications in the mouse bone marrow.
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OUP accepted manuscript
TL;DR: In this paper , the authors discuss recent advances in understanding the mechanisms that regulate stem cell regeneration and summarize potential strategies for rejuvenating stem cells that leverage intrinsic and extrinsic factors.
Journal ArticleDOI
Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells
Zhenhua Li,Quanli Yang,Xin Tang,Yiming Chen,Shanshan Wang,Xiaojie Qi,Yawen Zhang,Zonghua Liu,Jing Luo,Hui Liu,Yongbing Ba,Lianxia Guo,Baojian Wu,Fang Huang,Guangchao Cao,Zhinan Yin +15 more
TL;DR: In this article, a single-cell transcriptome and chromatin accessibility landscape of mouse γδ T cells in the lymph, spleen, and thymus was constructed.
Journal ArticleDOI
Human natural killer cells: form, function, and development.
TL;DR: In this paper , the authors provide an up-to-date and comprehensive overview of this important and interesting innate immune effector cell subset and address the clinical relevance of NK cells in both primary immunodeficiency and immunotherapy.
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