Interferon-γ stimulates the expression of galectin-9 in cultured human endothelial cells
Tadaatsu Imaizumi,Mika Kumagai,Naoko Sasaki,Hidekachi Kurotaki,Fumiaki Mori,Masako Seki,Nozomu Nishi,Koji Fujimoto,Kunikazu Tanji,Takeo Shibata,Wakako Tamo,Tomoh Matsumiya,Hidemi Yoshida,Xue-Fan Cui,Shingo Takanashi,Katsumi Hanada,Ken Okumura,Soroku Yagihashi,Koichi Wakabayashi,Takanori Nakamura,Mitsuomi Hirashima,Kei Satoh +21 more
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TLDR
IFN‐γ‐induced production of galectin‐9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils.Abstract:
Galectin-9 is a member of the galectin family and has been identified as an eosinophil chemoattractant produced by activated T lymphocytes. Vascular endothelial cells play an important role in the initial step of eosinophil recruitment and activation in immune and inflammatory responses. We have addressed the stimulation of galectin-9 expression in endothelial cells. Galectin-9 was detected in membrane and cytosolic fractions of human umbilical vein endothelial cells stimulated with interferon-gamma (IFN-gamma). IFN-gamma also enhanced the adhesion of human eosinophilic leukemia-1 cells to endothelial monolayers, and it was inhibited by the presence of lactose. Interleukin-4, which induces eotaxin expression, did not affect the expression of galectin-9. The in situ endothelium from patients with inflammatory diseases was found to express galectin-9. IFN-gamma-induced production of galectin-9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils.read more
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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Chen Zhu,Ana C. Anderson,Anna Schubart,Huabao Xiong,Jaime Imitola,Samia J. Khoury,Xin Xiao Zheng,Terry B. Strom,Vijay K. Kuchroo +8 more
TL;DR: The data suggest that the Tim-3–galectin-9 pathway may have evolved to ensure effective termination of effector TH1 cells.
Journal ArticleDOI
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Ana C. Anderson,David E. Anderson,Lisa Bregoli,William Hastings,Nasim Kassam,Charles Lei,Rucha Chandwaskar,Jozsef Karman,Ee W Su,Mitsuomi Hirashima,Jeffrey N. Bruce,Lawrence P. Kane,Vijay K. Kuchroo,David A. Hafler +13 more
TL;DR: It is found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors and can either promote or terminate TH1 immunity.
Journal ArticleDOI
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
Qing Zhou,Meghan E. Munger,Rachelle G. Veenstra,Brenda J. Weigel,Mitsuomi Hirashima,David H. Munn,William J. Murphy,Miyuki Azuma,Ana C. Anderson,Vijay K. Kuchroo,Bruce R. Blazar +10 more
TL;DR: Combined PD-1/PDL1 and Tim-3/galectin-9 blockade may be beneficial in preventing CD8(+) T-cell exhaustion in patients with hematologic malignancies such as advanced AML.
Journal ArticleDOI
Galectins in innate immunity: dual functions of host soluble β‐galactoside‐binding lectins as damage‐associated molecular patterns (DAMPs) and as receptors for pathogen‐associated molecular patterns (PAMPs)
TL;DR: The glycocalyx is a glycan layer found on the surfaces of host cells as well as microorganisms and enveloped virus, which contains various structurally different glycans, which provide cell‐ or microorganism‐specific ‘glycoinformation’ and is decoded by host glycan‐binding proteins, lectins.
Journal ArticleDOI
Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
Valerie Dardalhon,Ana C. Anderson,Jozsef Karman,Lionel Apetoh,Rucha Chandwaskar,David H. Lee,Melanie G. Cornejo,Nozomu Nishi,Akira Yamauchi,Francisco J. Quintana,Raymond A. Sobel,Raymond A. Sobel,Mitsuomi Hirashima,Vijay K. Kuchroo +13 more
TL;DR: The data uncover a novel mechanism by which the Tim-3/Gal-9 pathway regulates immune responses and identifies this pathway as a therapeutic target in diseases where myeloid-derived suppressor cells are disadvantageous.
References
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