International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
Dean M. Wingerchuk,Brenda Banwell,Jeffrey Bennett,Philippe Cabre,William M. Carroll,Tanuja Chitnis,Jérôme De Seze,Kazuo Fujihara,Benjamin Greenberg,Anu Jacob,Sven Jarius,Marco Aurélio Lana-Peixoto,Michael J. Levy,Jack H. Simon,Silvia Tenembaum,Anthony Traboulsee,Patrick Waters,Kay E. Wellik,Brian G. Weinshenker +18 more
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TLDR
The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasicNMOSD and opticospinal MS.Abstract:
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.read more
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International consensus diagnostic criteria for neuromyelitis optica spectrum disordersAuthor Response
TL;DR: Criteria for neuromyelitis optica (NMO) spectrum disorders (NMOSD) was proposed that incorporated unifying the terms NMO and NMOSD, including patients with aquaporin-4 (AQP4)–immunoglobulin G (IgG) negative/unknown, thus giving these patients …
References
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Journal ArticleDOI
Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: results from 211 lumbar punctures.
Sven Jarius,Friedemann Paul,Diego Franciotta,Klemens Ruprecht,Marius Ringelstein,Roberto Bergamaschi,Paulus S. Rommer,Ingo Kleiter,Oliver Stich,Reinhard Reuss,Sebastian Rauer,Uwe K. Zettl,Klaus-Peter Wandinger,Arthur Melms,Orhan Aktas,Wolfgang Kristoferitsch,Brigitte Wildemann +16 more
TL;DR: AQP4-Ab positive NMOSD is characterized by CSF features that are distinct from those in MS, and these findings are important for the differential diagnosis of MS andNMOSD and add to the understanding of the immunopathogenesis of this devastating condition.
Journal ArticleDOI
A secondary progressive clinical course is uncommon in neuromyelitis optica
Dean M. Wingerchuk,Sean J. Pittock,Claudia F. Lucchinetti,Vanda A. Lennon,Brian G. Weinshenker +4 more
TL;DR: The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.
Journal ArticleDOI
Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica
TL;DR: Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica but in none of 130 cases of multiple sclerosis (MS).
Journal ArticleDOI
Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications
B.F.Gh. Popescu,Vanda A. Lennon,Joseph E. Parisi,Charles L. Howe,Stephen D. Weigand,J.A. Cabrera-Gómez,Kathy L. Newell,Raul N. Mandler,Sean J. Pittock,Brian G. Weinshenker,Claudia F. Lucchinetti +10 more
TL;DR: These neuropathologic findings suggest the area postrema may be a selective target of the disease process in NMO, and are compatible with clinical reports of nausea and vomiting preceding episodes of optic neuritis and transverse myelitis or being the heralding symptom of NMO.
Journal ArticleDOI
Failure of natalizumab to prevent relapses in neuromyelitis optica.
Ingo Kleiter,Kerstin Hellwig,Achim Berthele,Tania Kümpfel,Ralf A. Linker,Hans-Peter Hartung,Friedemann Paul,Orhan Aktas +7 more
TL;DR: It is suggested that Neuromyelitis optica should be considered as a differential diagnosis in patients with suspected MS who are unresponsive to natalizumab therapy.
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