Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity.
Laís Salomão Arias,Juliano Pelim Pessan,Ana Paula Miranda Vieira,Taynara Maria Toito de Lima,Alberto Carlos Botazzo Delbem,Douglas Roberto Monteiro +5 more
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TLDR
This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms.Abstract:
Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.read more
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Engineering precision nanoparticles for drug delivery
Michael J. Mitchell,Margaret M. Billingsley,Rebecca M Haley,Marissa E. Wechsler,Nicholas A. Peppas,Robert Langer +5 more
TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.
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Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects
Pooyan Makvandi,Pooyan Makvandi,Pooyan Makvandi,Chen yu Wang,Ehsan Nazarzadeh Zare,Assunta Borzacchiello,Li Na Niu,Li Na Niu,Franklin R. Tay +8 more
TL;DR: An overview on the state‐of‐the‐art antimicrobial nanosized metal‐based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets, and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry.
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Metal Oxide Nanoparticles as Biomedical Materials
Maria P. Nikolova,Murthy Chavali +1 more
TL;DR: In this review, a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine are provided.
Journal ArticleDOI
A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection.
TL;DR: A docking study to explore the interaction of Iron oxide nanoparticles (Fe2O3 and Fe3O4) with the spike protein receptor binding domain of SARS-CoV-2 that is required for virus attachment to the host cell receptors revealed interactions of IONPs are expected to be associated with viral proteins conformational changes and hence, viral inactivation.
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Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
Shoeb Ansari,Eleonora Ficiarà,Federico Alessandro Ruffinatti,Ilaria Stura,Monica Argenziano,Ornella Abollino,Roberta Cavalli,Caterina Guiot,Federico D'Agata +8 more
TL;DR: The close link between physicochemical properties and magnetic characterization is described, essential to developing innovative and powerful magnetic-driven nanocarriers for Central Nervous System disorders.
References
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