Journal ArticleDOI
Large Potentials of Small Heat Shock Proteins
TLDR
All small heat shock proteins play important "housekeeping" roles and regulate many vital processes; therefore, they are considered as attractive therapeutic targets.Abstract:
Modern classification of the family of human small heat shock proteins (the so-called HSPB) is presented, and the structure and properties of three members of this family are analyzed in detail. Ub...read more
Citations
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Journal ArticleDOI
Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions.
TL;DR: Recent data are discussed that provide insight into the variety of structures of these proteins, their dynamic behavior, how they recognize substrates, and their many possible cellular roles.
Journal ArticleDOI
A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
TL;DR: Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can prevent the irreversible aggregation of denaturing proteins and have evolved independently in metazoans, plants and fungi.
Journal ArticleDOI
Plasma exosomes protect the myocardium from ischemia-reperfusion injury
Jose Miguel Vicencio,Derek M. Yellon,Derek M. Yellon,Vivek Sivaraman,Debashish Das,Claire Boi-Doku,Sapna Arjun,Ying Zheng,Jaime A. Riquelme,Jessica Kearney,Vikram Sharma,Gabriele Multhoff,Andrew R. Hall,Sean M. Davidson +13 more
TL;DR: The exosome-rich fraction was powerfully cardioprotective in all tested models of cardiac ischemia-reperfusion injury and identified a pro-survival signaling pathway activated in cardiomyocytes involving toll-like receptor (TLR) 4 and various kinases, leading to activation of the cardiop rotective HSP27.
Journal ArticleDOI
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses
Sadani N. Cooray,Thomas Gobbetti,Trinidad Montero-Melendez,Simon McArthur,Dawn Thompson,Adrian Clark,Roderick J. Flower,Mauro Perretti +7 more
TL;DR: The hypothesis that ALX might exist as homo- or heterodimer with FPR1 or FPR3 and operate in a ligand-biased fashion and indicate that agonist binding and dimerization state contribute to the conformational landscape of FPRs is tested.
Journal ArticleDOI
Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms
Luc Rochette,Charles Guenancia,Aurélie Gudjoncik,Olivier Hachet,Marianne Zeller,Yves Cottin,Catherine Vergely +6 more
TL;DR: Trastuzumab (TRZ), a humanized anti-HER2 monoclonal antibody, is currently recommended as first-line treatment for patients with metastatic HER2(+) tumors, but the use of TRZ may be limited by the development of drug intolerance, such as cardiac dysfunction.
References
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Jean François Rual,Kavitha Venkatesan,Tong Hao,Tomoko Hirozane-Kishikawa,Amélie Dricot,Ning Li,Gabriel F. Berriz,Francis D. Gibbons,Matija Dreze,Nono Ayivi-Guedehoussou,Niels Klitgord,Christophe Simon,Mike Boxem,Stuart Milstein,Jennifer Rosenberg,Debra S. Goldberg,Lan V. Zhang,Sharyl L. Wong,Giovanni Franklin,Siming Li,Joanna S. Albala,Joanna S. Albala,Janghoo Lim,Carlene Fraughton,Estelle Llamosas,Sebiha Cevik,Camille Bex,Philippe Lamesch,Robert S. Sikorski,Jean Vandenhaute,Huda Y. Zoghbi,Alex Smolyar,Stephanie Bosak,Reynaldo Sequerra,Lynn Doucette-Stamm,Michael E. Cusick,David E. Hill,Frederick P. Roth,Marc Vidal +38 more
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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Klarisa Rikova,Ailan Guo,Qingfu Zeng,Anthony Possemato,Jian Yu,Herbert Haack,Julie Nardone,Kimberly Lee,Cynthia Reeves,Yu Li,Yerong Hu,Zhi-Ping Tan,Matthew P. Stokes,Laura Sullivan,Jeffrey Mitchell,Randy Wetzel,Joan MacNeill,Jian Min Ren,Jin Yuan,Corey E. Bakalarski,Judit Villén,Jon M. Kornhauser,Bradley L. Smith,Daiqiang Li,Xinmin Zhou,Steven P. Gygi,Ting-Lei Gu,Roberto D. Polakiewicz,John Rush,Michael J. Comb +29 more
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Noah Dephoure,Chunshui Zhou,Judit Villén,Sean A. Beausoleil,Corey E. Bakalarski,Stephen J. Elledge,Steven P. Gygi +6 more
TL;DR: Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases, suggesting that many of the proteins identified may be CDK substrates.
Journal ArticleDOI
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
TL;DR: Although Hsp levels are not informative at the diagnostic level, they are useful biomarkers for carcinogenesis in some tissues and signal the degree of differentiation and the aggressiveness of some cancers.
Journal ArticleDOI
Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs.
TL;DR: The salivary glands and other tissues from Drosophila melanogaster were dissected at various times throughout the prepupal period, as well as after heat shocks and ecdysterone treatments, and the proteins labelled by incubating the isolated tissues with [35S]methionine were separated by electrophoresis on sodium dodecyl sulphate-polyacrylamide gel.