Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area.
Garret D. Stuber,F. Woodward Hopf,Junghyun Hahn,Saemi L. Cho,Anitra M. Guillory,Antonello Bonci +5 more
TL;DR: The results suggest that postsynaptic AMPAR function in VTA neurons was significantly enhanced after ethanol self-administration, and this activity observed here may facilitate the drive to consume ethanol.
Journal ArticleDOI
Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis
TL;DR: This study shows that excitatory synaptic transmission was enhanced in the bed nucleus of the stria terminalis of rats that performed an operant task to obtain cocaine or palatable food, suggesting that synaptic plasticity in this area is involved in reward-seeking behaviors.
Journal ArticleDOI
The Impact of Studying Brain Plasticity.
TL;DR: It is still not clear exactly how plasticity shapes brain morphology and physiology, but studying synaptic plasticity is clearly still important if the authors wish to fully understand how the brain works.
Journal ArticleDOI
Neuroprotection by Nicotine in Mouse Primary Cortical Cultures Involves Activation of Calcineurin and L-Type Calcium Channel Inactivation
TL;DR: It is concluded that neuroprotective effects of nicotine in cortical neurons involve both β2- and α7-containing nAChRs, activation of calcineurin, and decreased intracellular calcium via L-type channels.
Journal ArticleDOI
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear
Gemma L. Dalton,Dong Chuan Wu,Dong Chuan Wu,Yu Tian Wang,Stan B. Floresco,Anthony G. Phillips +5 more
TL;DR: Blocks in the thalamic-lateral amygdala pathway are shown to be involved specifically in the initial formation and/or stabilization of a learned fear response, whereas GluN2B receptor activation and associated LTD may facilitate the suppression of Pavlovian fear responses during extinction.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more