Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Long-term potentiation of intrinsic excitability in LV visual cortical neurons.
TL;DR: Activity-dependent plasticity in intrinsic excitability could greatly expand the computational power of individual neurons as well as serve as an important information storage mechanism.
Journal ArticleDOI
Activity-driven postsynaptic translocation of CaMKII.
TL;DR: An overview of recent progress in postsynaptic CaMKII anchoring is provided and its implication in synaptic plasticity and the etiology and potential treatments of neurological diseases is discussed.
Journal ArticleDOI
Effects of dendritic morphology on CA3 pyramidal cell electrophysiology: a simulation study
Jeffrey L. Krichmar,Slawomir J. Nasuto,Slawomir J. Nasuto,Ruggero Scorcioni,Stuart D. Washington,Giorgio A. Ascoli,Giorgio A. Ascoli +6 more
TL;DR: It is reported for the first time that differences in dendritic structure within the same morphological class can have a dramatic influence on the firing rate and firing mode (spiking versus bursting and type of bursting).
Journal ArticleDOI
Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
Robert E. McCullumsmith,Lars V. Kristiansen,Monica Beneyto,Elizabeth Scarr,Brian Dean,James H. Meador-Woodruff +5 more
TL;DR: It is proposed that the NMDA receptor signaling complex, including the intracellular machinery that is coupled to theNMDA receptor subunits, is abnormal in the hippocampus in bipolar disorder.
Journal ArticleDOI
Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation
Joshua P. Johansen,Lorenzo Diaz-Mataix,Hiroki Hamanaka,Takaaki Ozawa,Edgar A Ycu,Jenny Koivumaa,Ashwani Kumar,Mian Hou,Karl Deisseroth,Edward S. Boyden,Joseph E. LeDoux +10 more
TL;DR: Direct in vivo evidence is provided supporting the idea that a parallel mechanism involving neuromodulation and Hebbian processes is both necessary and sufficient to trigger synaptic strengthening and behavioral associative memory formation and suggesting that combined HeBBian and neurmodulatory processes interact to engage associative aversive learning.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
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