Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Escape Through a Small Opening: Receptor Trafficking in a Synaptic Membrane
TL;DR: This approach provides a framework for the theoretical study of receptor trafficking on membranes, where receptors are first inserted into the extrasynaptic plasma membrane and then random walk in and out of corrals through narrow openings on their way to their final destination.
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Organizing principles of real-time memory encoding : neural clique assemblies and universal neural codes
TL;DR: This work has shown that activation patterns of the neural clique assemblies can be converted to strings of binary codes that would permit universal categorizations of internal brain representations across individuals and species.
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Generalized Bienenstock-Cooper-Munro rule for spiking neurons that maximizes information transmission.
TL;DR: The synaptic update rule exhibits all of the features of the Bienenstock-Cooper-Munro rule, in particular, regimes of synaptic potentiation and depression separated by a sliding threshold.
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Dopamine Mediates Context-Dependent Modulation of Sensory Plasticity in C. elegans
Katie S. Kindt,Katie S. Kindt,Kathleen B. Quast,Kathleen B. Quast,Andrew C. Giles,Subhajyoti De,Dan Hendrey,Ian Nicastro,Catharine H. Rankin,William R Schafer,William R Schafer +10 more
TL;DR: Dopamine alters habituation kinetics by selectively modulating the touch responses of the anterior-body mechanoreceptors, forming a positive feedback loop capable of integrating context and experience to modulate mechanosensory attention.
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Glycine transporter type 1 blockade changes NMDA receptor‐mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels
Marzia Martina,Yelena Gorfinkel,Samantha Halman,John A. Lowe,Pranav Periyalwar,Christopher J. Schmidt,Richard Bergeron +6 more
TL;DR: The data suggest that the level of glycine present in the synaptic cleft tightly regulates the NMDAR activity, kept below the ‘set point’ of the N MDAR internalization priming mechanism by the presence of GlyT1‐dependent uptake.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more