Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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System A Transporter SAT2 Mediates Replenishment of Dendritic Glutamate Pools Controlling Retrograde Signaling by Glutamate
Monica Jenstad,Abrar Z. Quazi,Misha Zilberter,Camilla Haglerød,Paul Berghuis,Navida Saddique,Michel Goiny,Doungjai Buntup,Svend Davanger,Finn Mogens Haug,Carol A. Barnes,Bruce L. McNaughton,Ole Petter Ottersen,Jon Storm-Mathisen,Tibor Harkany,Farrukh A. Chaudhry +15 more
TL;DR: It is demonstrated that SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate in neurons containing dendrites.
Journal ArticleDOI
Hippocampal synaptic plasticity in mice devoid of cellular prion protein
TL;DR: The results indicate that mice devoid of normal cellular prion protein have an increased hippocampal synaptic plasticity which can be explained by a facilitated glutamatergic transmission.
Journal ArticleDOI
Uncoupling the D1-N-methyl-D-aspartate (NMDA) receptor complex promotes NMDA-dependent long-term potentiation and working memory.
Qiang Nai,Shupeng Li,Szu-Han Wang,Jing Liu,Frank J.S. Lee,Paul W. Frankland,Fang Liu,Fang Liu +7 more
TL;DR: A critical role of NMDA-D1 direct protein-protein interaction in NMDA receptor-mediated LTP and working memory is shown and the involvement of CaMKII is implicated in this process.
Journal ArticleDOI
Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation
Xiaohua Cao,Huimin Wang,Bing Mei,Bing Mei,Shu-Ming An,Liang Yin,L. Phillip Wang,Joe Z. Tsien +7 more
TL;DR: This study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain.
Journal ArticleDOI
Actin-Dependent Activation of Presynaptic Silent Synapses Contributes to Long-Term Synaptic Plasticity in Developing Hippocampal Neurons
Jun Yao,Jinshun Qi,Gong Chen +2 more
TL;DR: The results suggest that actin-dependent activation of presynaptic silent synapses contributes significantly to the long-term synaptic plasticity during neuronal development.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more