Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Enhanced contextual fear memory in central serotonin-deficient mice
Jin-Xia Dai,Huili Han,Meng Tian,Jun Cao,Jian-Bo Xiu,Ning-Ning Song,Ying Huang,Tian-Le Xu,Yu-Qiang Ding,Lin Xu +9 more
TL;DR: The enhanced fear memory in 5- HT-deficient mice supports the notion that 5-HT deficiency confers susceptibility to posttraumatic stress disorder in humans and regulates hippocampus-dependent contextual fear memory, and5-HT modulation of hippocampal synaptic plasticity may be the underlying mechanism.
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Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII
Michael C. Oh,Victor A. Derkach +1 more
TL;DR: This work defines a previously unknown, dominant role of the GluR2 subunit in signaling mediated by CaMKII at AMPARs, and preserves the functional regulation of AM PARs by phosphorylation by Ca MKII.
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Developmental Periods of Choline Sensitivity Provide an Ontogenetic Mechanism for Regulating Memory Capacity and Age-Related Dementia
TL;DR: It is demonstrated that the availability of choline during critical periods of brain development influences cognitive performance in adulthood and old age, and the importance of perinatal nutrition for successful cognitive aging is emphasized.
Journal ArticleDOI
A biophysically based neural model of matching law behavior: melioration by stochastic synapses.
Alireza Soltani,Xiao Jing Wang +1 more
TL;DR: The results suggest that neurons in LIP are involved in selecting the oculomotor responses, whereas rewards are integrated and stored elsewhere, possibly by plastic synapses and in the form of the return rather than income of choice options.
Journal ArticleDOI
Synaptic Influence of Hippocampus on Pyramidal Cells of the Rat Prefrontal Cortex: An In Vivo Intracellular Recording Study
TL;DR: The characteristics of the synaptic transmission in the hippocampo-prefrontal cortex pathway further supports the existence of a cooperative relationship between two structures known to be involved in higher cognitive processes.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
Related Papers (5)
A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more