Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Journal ArticleDOI
Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.
TL;DR: Using receptor antagonists, as well as receptor knockout mice, it is found that presynaptic kainate receptors facilitate the induction of mossy fiber long-term potentiation (LTP), although they are not required for this form of LTP.
Journal ArticleDOI
Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging
Judith L. Rapoport,Nitin Gogtay +1 more
TL;DR: Diagnostically specific, illness-related changes as well as outcome-associated plastic response are observed as illustrated for two pediatric populations, childhood-onset schizophrenia and attention-deficit/hyperactivity disorder, conditions which may be, in part, disorders of brain plasticity.
Book ChapterDOI
The developing brain and neural plasticity: Implications for normality, psychopathology, and resilience.
Dante Cicchetti,W. John Curtis +1 more
TL;DR: This chapter discusses the development of brain development in Atypical Populations, and some of the principles of development and future directions are outlined.
Journal ArticleDOI
Silent synapses in neural plasticity: current evidence.
TL;DR: In several nervous systems, evidence from electrophysiological and optophysiological measurements has established a strong case for the existence of silent synapses and for their emergence as active synapses with appropriate stimulation.
Journal ArticleDOI
Novel presynaptic mechanisms for coincidence detection in synaptic plasticity.
Ian Duguid,Per Jesper Sjöström +1 more
TL;DR: A large number of studies indicate the existence of presynaptic coincidence detection that is independent of NMDA receptors, suggesting that such mechanisms have a widespread role in plasticity.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
Related Papers (5)
A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more