Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Journal ArticleDOI
Auxiliary Subunits Assist AMPA-Type Glutamate Receptors
TL;DR: The pivotal role that TARPs play in the life cycle of AMPA receptors is reviewed and it is shown that a family of small transmembrane AMPA receptor regulatory proteins (TARPs) controls both AMPAceptor trafficking and channel gating.
Journal ArticleDOI
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
Wei-Dong Yao,Raul R. Gainetdinov,Margaret I. Arbuckle,Tatyana D. Sotnikova,Michel Cyr,Jean-Martin Beaulieu,Gonzalo E. Torres,Seth G. N. Grant,Seth G. N. Grant,Marc G. Caron +9 more
TL;DR: A previously unappreciated role of PSD-95 in psychostimulant action is uncovered and a molecular and cellular mechanism shared between drug-related plasticity and learning is identified.
Journal ArticleDOI
Stimulation in Hippocampal Region CA1 in Behaving Rats Yields Long-Term Potentiation when Delivered to the Peak of Theta and Long-Term Depression when Delivered to the Trough
TL;DR: This is the first report of LTP being preferentially induced at the peak of local theTA rhythm in behaving animals in region CA1 and that LTD was found in response to tetanic stimulation at the trough of the local theta wave.
Patent
Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
Bradford Evan Gliner,Allen Wyler,Brad Fowler,W. Douglas Sheffield,Richard Kuntz,Kent W. Leyde,Leif R. Sloan +6 more
TL;DR: In this article, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain over another set of stimulating parameters.
Journal ArticleDOI
Synapse-specific regulation of AMPA receptor function by PSD-95
TL;DR: A synapse-specific role for PSD-95 in controlling synaptic function that is independent of spine morphology is suggested, which is related to the greater magnitude of potentiation after long-term potentiation induction observed in these mice.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more