Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
Reads0
Chats0
TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
More filters
Journal ArticleDOI
NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala
TL;DR: The results suggest that two pharmacologically distinct forms of LTP can be isolated in the LA in vitro and that a combination of both contribute to the formation of fear memories in vivo at the cellular level.
Journal ArticleDOI
eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory
Mauro Costa-Mattioli,Delphine Gobert,Elad Stern,Karine Gamache,Rodney Colina,Claudio Cuello,Wayne S. Sossin,Randal J. Kaufman,Jerry Pelletier,Kobi Rosenblum,Krešimir Krnjević,Jean-Claude Lacaille,Karim Nader,Nahum Sonenberg +13 more
TL;DR: It is shown that in eIF2alpha(+/S51A) mice, in which eif2alpha phosphorylation is reduced, the threshold for eliciting L-LTP in hippocampal slices is lowered, and memory is enhanced, and the importance of a single phosphorylated site in e IF2alpha as a key regulator of L- LTP and LTM formation is highlighted.
Journal ArticleDOI
Synchronous Gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia
TL;DR: It is concluded that measures of Gamma synchrony offer a valuable window into the core integrative disturbance in schizophrenia cognition.
Journal ArticleDOI
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
TL;DR: The ECM has a dual role as a promoter of structural and functional plasticity and as a degradable stabilizer of neural microcircuits, likely to be important for mental health.
Journal ArticleDOI
Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines.
Karin E. Sorra,Kristen M. Harris +1 more
TL;DR: A review on the structure, composition, function, development, plasticity, and pathology of hippocampal dendritic spines can be found in the special issue of Hippocampus as mentioned in this paper.
References
More filters
Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
Related Papers (5)
A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more