Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Postsynaptic protein phosphorylation and LTP.
TL;DR: In the CA1 region of the hippocampus, the combined activation of SRC family tyrosine kinases, protein kinase A,protein kinase C and, in particular, Ca2+/calmodulin-dependent protein kinases II results in phosphorylation of glutamate-receptor-gated ion channels and the enhancement of subsequent postsynaptic current.
Journal ArticleDOI
Synaptic strength regulated by palmitate cycling on PSD-95
Alaa El-Husseini,Eric Schnell,Srikanth Dakoji,Neal T. Sweeney,Qiang Zhou,Oliver Prange,Catherine Gauthier-Campbell,Andrea Aguilera-Moreno,Roger A. Nicoll,David S. Bredt +9 more
TL;DR: It is found that palmitate cycling on PSD-95 can regulate synaptic strength and regulates aspects of activity-dependent plasticity, and that rapid glutamate-mediated AMPA receptor internalization requires depalmitoylation of PSd-95.
Journal ArticleDOI
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system.
TL;DR: The development of methods to remove CSPGs has considerable therapeutic potential in a number of CNS disorders and may be involved in the pathological processes in diseases such as epilepsy, stroke and Alzheimer's disease.
Journal ArticleDOI
Neuromorphic computing with multi-memristive synapses
Irem Boybat,Irem Boybat,Manuel Le Gallo,S. R. Nandakumar,S. R. Nandakumar,Timoleon Moraitis,Thomas Parnell,Tomas Tuma,Bipin Rajendran,Yusuf Leblebici,Abu Sebastian,Evangelos Eleftheriou +11 more
TL;DR: A multi-memristive synaptic architecture with an efficient global counter-based arbitration scheme to address challenges associated with the non-ideal memristive device behavior is proposed.
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Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
Susumu Tomita,Lu Chen,Yoshimi Kawasaki,Ronald S. Petralia,Robert J. Wenthold,Roger A. Nicoll,David S. Bredt +6 more
TL;DR: A general role for TARPs is indicated in controlling synaptic AMPA receptors throughout the central nervous system.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more