Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.
Michael A. Nitsche,Walter Paulus +1 more
TL;DR: Transcranial electrical stimulation using weak current may be a promising tool to modulate cerebral excitability in a non‐invasive, painless, reversible, selective and focal way.
Journal ArticleDOI
Neurotrophins: roles in neuronal development and function.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.
Journal ArticleDOI
Memory--a century of consolidation.
TL;DR: This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories.
Journal ArticleDOI
LTP and LTD: an embarrassment of riches.
Robert C. Malenka,Mark F. Bear +1 more
TL;DR: This work reviews those forms of LTP and LTD for which mechanisms have been most firmly established and examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.
Journal ArticleDOI
Neuronal plasticity: increasing the gain in pain.
TL;DR: Here, a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain is developed, identifying distinct forms of Plasticity, which are term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
References
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Journal ArticleDOI
Monitoring Glutamate Release during LTP with Glial Transporter Currents
TL;DR: Glial cell responses were very sensitive to manipulations known to change the release of glutamate yet remained constant during LTP, arguing strongly for a postsynaptic expression mechanism for LTP.
Journal ArticleDOI
A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons
TL;DR: It is indicated that rises in intracellular Ca2+ that occur independently of NMDA receptor activation can result in a potentiation of quantal size, which is due to an increase in the postsynaptic sensitivity of non-NMDA receptors.
Journal ArticleDOI
Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity
TL;DR: A new model for induction of LTP whereby tetanic stimulation produces a rapid activation of Src, causing enhanced NMDA receptor function, which boosts the entry of Ca2+, which may thereby trigger the downstream signalling cascade, ending in potentiation of non-NMDA receptors.
Journal ArticleDOI
Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells.
TL;DR: The results suggest that the mechanism for the expression of LTP involves a increase in q and is difficult to explain by an increase in Pr alone, suggesting that synapses with high Pr can express LTP.
Book ChapterDOI
Activity-dependent development of the vertebrate nervous system.
R D Fields,P G Nelson +1 more
TL;DR: This chapter discusses the experiments on the role of activity during development from many different systems, principally the neuromuscular junction (NMJ), the retinal/tectal system, the visual cortex, long-term potentiation in the hippocampus, and a number of other vertebrate systems where this question is studied.
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