Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Increased d-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice
Francesco Errico,Robert Nisticò,Francesco Napolitano,Carmen Mazzola,Dalila Astone,Teresa Pisapia,Michela Giustizieri,Antimo D'Aniello,Nicola Biagio Mercuri,Alessandro Usiello +9 more
TL;DR: It is shown that oral administration of D-Asp strongly enhances NMDAR-dependent LTP in adulthood and completely rescues the synaptic plasticity decay observed in the hippocampus of aged animals, suggesting a tantalizing hypothesis for which this in-embryo-occurring D-amino acid may disclose plasticity windows inside which it counteracts the age-related reduction of N MDAR signaling.
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Structure and molecular organization of dendritic spines
Ayumu Tashiro,Rafael Yuste +1 more
TL;DR: The structural aspects of dendritic spines are reviewed, with particular emphasis on recent advances in the characterization of their molecular components, suggesting that spires are paramount examples of biological nanotechnology.
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Learning in simple systems.
TL;DR: Cellular processes that mediate learning and memory show a remarkable level of conservation between vertebrates and invertebrates and may act in series or in parallel during various stages of memory formation.
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Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms.
TL;DR: The findings suggest that BDNF-mediated GluR1 tyrosine phosphorylation potentially regulates synaptic plasticity postsynaptically through NR2B subunits of the NMDA receptor.
Journal ArticleDOI
The neurophysiology of language: Insights from non-invasive brain stimulation in the healthy human brain.
TL;DR: Novel approaches such as multifocal transcranial magnetic stimulation and the condition-and-perturb approach are discussed, particularly suited to investigate short-term reorganization in the healthy brain and may inform models of language recovery in post-stroke aphasia.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
Related Papers (5)
A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more