Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
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Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD
Jennifer D. Petersen,Xiaobing Chen,Lucia Vinade,Ayse Dosemeci,John E. Lisman,Thomas S. Reese +5 more
TL;DR: The positions of calcium/calmodulin-dependent protein kinase II (CaMKII) and PSD-95 within the three-dimensional structure of isolated PSDs are determined using immunogold labeling, rotary shadowing, and electron microscopic tomography.
Journal ArticleDOI
AMPA Receptor Trafficking and the Control of Synaptic Transmission
Morgan Sheng,Sang Hyoung Lee +1 more
TL;DR: Recent work from Roberto Malinow and colleagues, culminating in a paper in Cell, has defined an important set of subunitspecific rules governing the delivery of AMPA receptors to synapses, providing new insights into the postsynaptic trafficking of AMpa receptors and open inroads into the molecular mechanisms that tune synaptic strength.
Journal ArticleDOI
Long-term potentiation in spinothalamic neurons
TL;DR: It is hypothesized that central sensitization of STT neurons is a variety of long-term potentiation (LTP), and it is proposed that the phosphorylation of neurotransmitter receptors leads to alterations in the sensitivity of these receptors and tocentral sensitization.
Journal ArticleDOI
Tyrosine Phosphatase STEP Is a Tonic Brake on Induction of Long-Term Potentiation
Kenneth A Pelkey,Rand Askalan,Surojit Paul,Lorraine V. Kalia,Tri Nguyen,Graham M. Pitcher,Michael W. Salter,Paul J. Lombroso +7 more
TL;DR: It is shown that striatal enriched tyrosine phosphatase (STEP) is a component of the N-methyl-D-aspartate receptor (NMDAR) complex and acts as a tonic brake on synaptic transmission by opposing Src-dependent upregulation of NMDARs.
Journal ArticleDOI
Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure.
TL;DR: The present results indicate that potentiation of GABAergic synapses, via a PKA-dependent mechanism, occurs in the VTA after a single in vivo exposure to ethanol, and such potentiation might be a key synaptic modification underlying increased ethanol intake.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more