Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Actin dynamics in dendritic spines: a form of regulated plasticity at excitatory synapses.
TL;DR: Dendritic spines form the postsynaptic element at most excitatory synapses in the brain and, in time‐lapse recordings of living neurons expressing actin labeled with green fluorescent protein, can be seen to undergo rapid, dynamic changes.
Journal ArticleDOI
Extent of Dorsolateral Prefrontal Cortex Plasticity and Its Association With Working Memory in Patients With Alzheimer Disease.
Sanjeev Kumar,Sanjeev Kumar,Reza Zomorrodi,Zaid Ghazala,Zaid Ghazala,Zaid Ghazala,Michelle S. Goodman,Michelle S. Goodman,Daniel M. Blumberger,Daniel M. Blumberger,Daniel M. Blumberger,Amay Cheam,Amay Cheam,Corinne E. Fischer,Corinne E. Fischer,Zafiris J. Daskalakis,Zafiris J. Daskalakis,Zafiris J. Daskalakis,Benoit H. Mulsant,Benoit H. Mulsant,Benoit H. Mulsant,Bruce G. Pollock,Bruce G. Pollock,Bruce G. Pollock,Tarek K. Rajji,Tarek K. Rajji,Tarek K. Rajji +26 more
TL;DR: The findings support the use of D LPFC plasticity as a measure of DLPFC function and a potential treatment target to enhance DLP FC function and working memory in patients with AD.
Journal ArticleDOI
Regulation of signal transduction by protein targeting: the case for CaMKII.
K. Ulrich Bayer,Howard Schulman +1 more
TL;DR: The interaction of CaMKII with the NMDA receptor shows that a targeting protein can not only specify the subcellular localization of a signaling effector, but can also directly influence its regulation.
Journal ArticleDOI
A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function
TL;DR: A mammalian nervous-system-specific membrane proteasome complex is described that directly and rapidly modulates neuronal function by degrading intracellular proteins into extracellular peptides that can stimulate neuronal signaling.
Journal ArticleDOI
CaMKIIβ association with the actin cytoskeleton is regulated by alternative splicing
TL;DR: It is shown that F-actin-targeted CaMKIIbeta, but not alpha, was able to phosphorylate actin in vitro even by nonstimulated basal activity in absence of Ca(2+)/CaM.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more