Journal ArticleDOI
Long-Term Potentiation--A Decade of Progress?
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TLDR
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.Abstract:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.read more
Citations
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Journal ArticleDOI
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa.
Anna Aiello,Monica D’Esposito,Ernesto Fattorusso,Marialuisa Menna,Werner E.G. Müller,Sanja Perović-Ottstadt,Heinz C. Schröder +6 more
TL;DR: Four novel alkaloids of this class, compounds 1-4, have been isolated, and their structures established through spectroscopic methods and were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.
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Near-future CO2 levels impair the olfactory system of a marine fish
Cosima S. Porteus,Peter C. Hubbard,Tamsyn M. Uren Webster,Ronny van Aerle,Adelino V.M. Canario,Eduarda M. Santos,Rod W. Wilson +6 more
TL;DR: These findings complement the previously proposed impairment of γ-aminobutyric acid receptors, and indicate that both the olfactory system and central brain function are compromised by elevated CO2 levels.
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Contralaterally Controlled Functional Electrical Stimulation for Upper Extremity Hemiplegia: An Early-Phase Randomized Clinical Trial in Subacute Stroke Patients
Jayme S. Knutson,Mary Y. Harley,Terri Z. Hisel,Shannon D. Hogan,Margaret M. Maloney,John Chae,John Chae +6 more
TL;DR: The results favor CCFES over cyclic NMES Though the small sample size limits the statistical power of the study, the effect size estimates will be used to power a larger trial.
Book ChapterDOI
Neurosteroids in learning and memory processes.
TL;DR: This chapter summarizes the effects of the administration of neurosteroids on learning and memory capabilities in rodents and in models of amnesia, and addresses the central mechanisms involved in mediating the modulation oflearning and memory processes by neurosteroid.
Journal ArticleDOI
Biophysical model of synaptic plasticity dynamics
TL;DR: A biophysical model of synaptic plasticity is discussed that provides a unified view of the outcomes of synaptic modification protocols, including prescribed time courses of postsynaptic intracellular Ca2+ release and LTP/LTD as a response to precisely timed presynaptic and post Synaptic spikes.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.
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A synaptic model of memory: long-term potentiation in the hippocampus
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more