Journal ArticleDOI
m 6 A RNA methylation: from mechanisms to therapeutic potential
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TLDR
The role of m6-methyladenosine (m6 A) in post-transcriptional gene expression regulation is discussed in this article, where the authors highlight advances in the understanding of the m6 A deposition on mRNA and its context-dependent effects on mRNA decay and translation.Abstract:
RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N6 -methyladenosine (m6 A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification. m6 A methylation regulates gene expression by influencing numerous aspects of mRNA metabolism, including pre-mRNA processing, nuclear export, decay, and translation. The importance of m6 A methylation as a mode of post-transcriptional gene expression regulation is evident in the crucial roles m6 A-mediated gene regulation plays in numerous physiological and pathophysiological processes. Here, we review current knowledge on the mechanisms by which m6 A exerts its functions and discuss recent advances that underscore the multifaceted role of m6 A in the regulation of gene expression. We highlight advances in our understanding of the regulation of m6 A deposition on mRNA and its context-dependent effects on mRNA decay and translation, the role of m6 A methylation of non-coding chromosomal-associated RNA species in regulating transcription, and the activities of the RNA demethylase FTO on diverse substrates. We also discuss emerging evidence for the therapeutic potential of targeting m6 A regulators in disease.read more
Citations
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m6A modification: recent advances, anticancer targeted drug discovery and beyond
Lijuan Deng,Weilun Deng,Shunming Fan,Minfeng Chen,Ming-Xiu Qi,Wen-Yu Lyu,Qi Qi,Amit K. Tiwari,Jiaxu Chen,Dong-Mei Zhang,Zhe S Chen +10 more
TL;DR: In this article , the authors provide an update of the latest findings on m6A modification and the critical roles of modification in cancer progression, and summarize rational sources for the discovery of M6A-targeted anticancer agents from traditional medicines and computer-based chemosynthetic compounds.
Journal ArticleDOI
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Lijuan Deng,Weilun Deng,Shu-Ran Fan,Minfeng Chen,Ming-Xiu Qi,Wen-Yu Lyu,Qi Qi,Amit K. Tiwari,Jia Xu Chen,Dong-Mei Zhang,Zhe-Sheng Chen +10 more
TL;DR: In this article , the authors provide an update of the latest findings on m6A modification and the critical roles of modification in cancer progression, and summarize rational sources for the discovery of M6A-targeted anticancer agents from traditional medicines and computer-based chemosynthetic compounds.
Journal ArticleDOI
Targeting the RNA m6A modification for cancer immunotherapy
TL;DR: In this paper , an up-to-date and comprehensive overview of how m6A modifications intrinsically affect immune cells and how alterations in tumor cell modifications extrinsically affect immune cell responses in the tumor microenvironment (TME).
Journal ArticleDOI
The plasticity of mRNA translation during cancer progression and therapy resistance.
Lucilla Fabbri,Lucilla Fabbri,Alina Chakraborty,Alina Chakraborty,Caroline Robert,Caroline Robert,Stéphan Vagner +6 more
TL;DR: The role of mRNA translation in the cellular response to anticancer therapies and its promise as a key therapeutic target is discussed in this article. But the translational rewiring of mRNAs during gene expression allows rapid, specific changes in the cell proteome that shape specific cancer phenotypes to promote cancer onset, progression, and resistance to anti-cancer therapies.
Journal ArticleDOI
Targeting the RNA m6A modification for cancer immunotherapy
TL;DR: In this paper , an up-to-date and comprehensive overview of how m6A modifications intrinsically affect immune cells and how alterations in tumor cell modifications extrinsically affect immune cell responses in the tumor microenvironment (TME).
References
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N6-methyladenosine-dependent regulation of messenger RNA stability
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