Journal ArticleDOI
Mechanical properties and the hierarchical structure of bone
TLDR
Further investigations of mechanical properties at the "materials level", in addition to the studies at the 'structural level' are needed to fill the gap in present knowledge and to achieve a complete understanding of the mechanical properties of bone.About:
This article is published in Medical Engineering & Physics.The article was published on 1998-03-01. It has received 2352 citations till now.read more
Citations
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Cell-laden biphasic scaffolds with anisotropic structure for the regeneration of osteochondral tissue.
TL;DR: The development of biphasic, but monolithic scaffolds based on alginate, which are suitable for embedding of living cells in the chondral part are described, demonstrating successful fabrication of cell‐laden centimetre‐scaled constructs for potential application in regenerative treatment of osteochondral defects.
Journal ArticleDOI
Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteogenic Differentiation
Alessandra Procopio,Emil Malucelli,Alexandra Pacureanu,Concettina Cappadone,Giovanna Farruggia,Azzurra Sargenti,Sara Castiglioni,Davide Altamura,Andrea Sorrentino,Cinzia Giannini,Eva Pereiro,Peter Cloetens,Jeanette A.M. Maier,Stefano Iotti +13 more
TL;DR: It is demonstrated that biomineralization starts with Zn–hydroxyapatite nucleation within the cell, rapidly evolving toward hexagonal hydroxyapatites crystals, very similar in composition and structure to the one present in human bone.
Journal ArticleDOI
3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives.
Lijia Cheng,Shoma Suresh K,Hongyan He,Ritu Singh Rajput,Qiyang Feng,S. Ramesh,Yuzhuang Wang,Sasirekha Krishnan,Serge Ostrovidov,Gulden Camci-Unal,Murugan Ramalingam +10 more
TL;DR: A comprehensive overview of the 3D printing methods such as stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM), and ink-jet printing, and their technical and clinical applications in bone repair and regeneration has been provided as discussed by the authors.
Journal ArticleDOI
High strain rate mechanical behavior of seashell-mimetic composites: Analytical model formulation and validation
TL;DR: In this article, an attempt has been made to predict the strength of these types of composites under dynamic regime by development of an analytical model, followed by experimental verification under high-strain rates using Split Hopkinson Pressure Bar (SHPB).
Journal ArticleDOI
Effect of laminated hydroxyapatite/gelatin nanocomposite scaffold structure on osteogenesis using unrestricted somatic stem cells in rat.
Shima Tavakol,Mahmoud Azami,Ahad Khoshzaban,Iraj Ragerdi Kashani,Behnaz Tavakol,Elham Hoveizi,Seyed Mahdi Rezayat Sorkhabadi,Seyed Mahdi Rezayat Sorkhabadi +7 more
TL;DR: Osteoblast differentiation and bone regeneration results of in vitro and in vivo investigation on scaffold were extremely significant, better than control and treatment groups, and confirm the feasibility of bone regeneration using synthesised scaffold as a temporary bone substitute.
References
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Journal ArticleDOI
The compressive behavior of bone as a two-phase porous structure.
Dennis R. Carter,Wilson C. Hayes +1 more
TL;DR: These power relationships, which were shown to hold for all bone in the skeleton, allow meaningful predictions of bone tissue strength and stiffness based on in vivo density measurements.
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Young's modulus of trabecular and cortical bone material: ultrasonic and microtensile measurements.
TL;DR: The results suggest that when considered mechanically, cortical and trabecular bone are not the same material.
Journal ArticleDOI
The mechanical behaviour of cancellous bone
TL;DR: The results of this previous study are applied to cancellous bone in an attempt to further understand its mechanical behaviour and the results agree reasonably well with experimental data available in the literature.
Journal ArticleDOI
Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation
TL;DR: An experimental investigation was undertaken to measure the intrinsic elastic properties of several of the microstructural components of human vertebral trabecular bone and tibial cortical bone by the nanoindentation method, and differences in the measured moduli are statistically significant.