Journal ArticleDOI
Mechanical properties and the hierarchical structure of bone
TLDR
Further investigations of mechanical properties at the "materials level", in addition to the studies at the 'structural level' are needed to fill the gap in present knowledge and to achieve a complete understanding of the mechanical properties of bone.About:
This article is published in Medical Engineering & Physics.The article was published on 1998-03-01. It has received 2352 citations till now.read more
Citations
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Journal ArticleDOI
Development of nanomaterials for bone repair and regeneration.
TL;DR: Current fabrication techniques for nanomaterials and nanocomposites, their cell interaction properties and their application in bone tissue engineering and regeneration are reviewed.
Journal ArticleDOI
Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review
Mythili Prakasam,Janis Locs,Kristine Salma-Ancane,Dagnija Loča,Alain Largeteau,Liga Berzina-Cimdina +5 more
TL;DR: In this paper, a review of the various applications of dense hydroxyapatite and other dense biomaterials on the aspects of transparency and the mechanical and electrical behavior is presented.
Journal ArticleDOI
Spatially patterned matrix elasticity directs stem cell fate.
Chun Yang,Frank W. DelRio,Hao Ma,Anouk R. Killaars,Lena P. Basta,Kyle A. Kyburz,Kristi S. Anseth +6 more
TL;DR: It is inferred that irregular, disorganized variations in matrix mechanics appear to disrupt actin organization, and lead to different cell fates; this was verified by observations of lower alkaline phosphatase (ALP) activity and higher expression of CD105, a stem cell marker, in hMSCs in random versus regular patterns of mechanical properties.
Journal ArticleDOI
3D artificial bones for bone repair prepared by computed tomography-guided fused deposition modeling for bone repair
TL;DR: PCL/HA 3D artificial bones prepared by CT-guided FDM have more close mechanics to natural bone, good in vitro cell biocompatibility, biodegradation ability, and appropriate in vivo new bone formation ability and could be potentially be of use in the treatment of patients with clinical bone defects.
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Multiscale modeling of elastic properties of cortical bone
TL;DR: In this paper, the authors predict the elastic constants of cortical bone by modeling its elastic response at these different scales, spanning from the nanostructural to messtructural levels, using micromechanics methods and composite materials laminate theories.
References
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Journal ArticleDOI
The compressive behavior of bone as a two-phase porous structure.
Dennis R. Carter,Wilson C. Hayes +1 more
TL;DR: These power relationships, which were shown to hold for all bone in the skeleton, allow meaningful predictions of bone tissue strength and stiffness based on in vivo density measurements.
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Young's modulus of trabecular and cortical bone material: ultrasonic and microtensile measurements.
TL;DR: The results suggest that when considered mechanically, cortical and trabecular bone are not the same material.
Journal ArticleDOI
The mechanical behaviour of cancellous bone
TL;DR: The results of this previous study are applied to cancellous bone in an attempt to further understand its mechanical behaviour and the results agree reasonably well with experimental data available in the literature.
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Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation
TL;DR: An experimental investigation was undertaken to measure the intrinsic elastic properties of several of the microstructural components of human vertebral trabecular bone and tibial cortical bone by the nanoindentation method, and differences in the measured moduli are statistically significant.