Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
Reads0
Chats0
TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
More filters
Journal ArticleDOI
Cellular and mitochondrial calcium communication in obstructive lung disorders.
TL;DR: In this paper, a review highlights the key role of cytoplasmic and mitochondrial Ca2+ signalling in regulating CRD, such as asthma and COPD, which could provide cues for the development of advanced therapeutic interventions in these diseases.
Journal ArticleDOI
Circulating fibrocytes correlate with the asthma control test score.
Hiroyasu Kobayashi,Masahiro Naito,Masahiro Masuya,Mitsuko Maruyama,Kentaro Urata,Yoshinori Takahashi,Atsushi Tomaru,Kentaro Fujiwara,M. Ohnishi,Takehiro Takagi,Tetsu Kobayashi,Corina N. D’Alessandro-Gabazza,Masahito Urawa,Esteban C. Gabazza,Osamu Taguchi,Yoshiyuki Takei +15 more
TL;DR: The results of this study showed that the number of circulating fibrocytes is inversely correlated with clinical asthma control parameters, further supporting the relevance of measuring circulating fibracytes as a marker of clinical control in bronchial asthma.
Journal ArticleDOI
Conhecimento sobre asma de pediatras de hospitais públicos do Rio de Janeiro
TL;DR: In this article, the authors present a study of the relationship between the Faculdade de Medicina de Petrópolis and the Departamento de Pediatria of the Universidade Federal do Rio de Janeiro.
Book ChapterDOI
Airway Remodelling in Asthma
TL;DR: Close interactions tightly connect the cellular and molecular mechanisms underpinning airway inflammation and remodelling, and both pathologic processes certainly contribute together to induce bronchial hyperresponsiveness as well as asthma persistence and progression, especially in most severe disease phenotypes.
Journal ArticleDOI
Two-stage Contextual Transformer-based Convolutional Neural Network for Airway Extraction from CT Images
Yanan Wu,Shuiqing Zhao,Shouliang Qi,Jie Feng,Haowen Pang,Runsheng Chang,Long Bai,Meng-Yi Li,Shuyue Xia,Wei Qian,Hongliang Ren +10 more
TL;DR: Zhang et al. as mentioned in this paper proposed a two-stage 3D contextual transformer-based U-Net for airway segmentation using CT images, which consists of two stages, performing initial and re-formed airway segments.
References
More filters
Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.