Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
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TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
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Journal ArticleDOI
Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.
Ji Young Kang,Mi Ran Jo,Hyeon Hui Kang,Sung Kyoung Kim,Myoung Sook Kim,Yong Hyun Kim,Seok Chan Kim,Soon Seog Kwon,Sook Young Lee,Jin Woo Kim +9 more
TL;DR: This study suggests that in a murine model of chronic asthma, long-term azithromycin treatment ameliorates not only airway inflammation but also airway remodeling by influencing on neutrophilc-related mediators, BRP-39 and MAPK/NF-κB signal pathways.
Journal ArticleDOI
8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: role in asthma pathogenesis
TL;DR: DNA's integrity must be maintained to prevent mutation, so its continuous repair and downstream signaling ‘fuel’ chronic inflammatory processes in asthma and form the basic mechanism whose elucidation will allow the development of new drug targets for the prevention/reversal of lung diseases.
Journal ArticleDOI
Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and the proliferation of airway smooth muscle cells.
TL;DR: The results provide evidences to support the hypothesis that PMCA is involved in the regulation of Ca2+ homeostasis and ASMCs proliferation and suggest thatPMCA may be a new target in the treatment of chronic asthma.
Journal ArticleDOI
Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.
Randa Belgacemi,Emilie Luczka,Julien Ancel,Zania Diabasana,Jeanne-Marie Perotin,Adeline Germain,Nathalie Lalun,Philippe Birembaut,Xavier Dubernard,Jean-Claude Mérol,Gonzague Delepine,Myriam Polette,Gaëtan Deslée,Valérian Dormoy +13 more
TL;DR: The data suggest that HH pathway is crucial for airway epithelial cell differentiation and highlight its role in COPD-associated epithelial remodelling and Gli2 activating transcription factor was demonstrated as a key-element in the regulation of AEC differentiation.
Journal ArticleDOI
Moderate hyperoxia induces extracellular matrix remodeling by human fetal airway smooth muscle cells.
Elizabeth R. Vogel,Rodney D. Britt,Arij Faksh,Ine Kuipers,Hitesh Pandya,Y. S. Prakash,Richard J. Martin,Christina M. Pabelick +7 more
TL;DR: It is demonstrated that moderate hyperoxia enhances ECM deposition in developing airways by altering the balance between MMPs and their inhibitors (TIMPs), and by increasing collagen deposition.
References
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Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
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Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.