Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
Reads0
Chats0
TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
More filters
Journal ArticleDOI
Hydrogen sulfide inhibits transforming growth factor beta-1 induced bronchial epithelial-mesenchymal transition.
TL;DR: Recent researches have shown that epithelial‐mesenchymal transition (EMT) is one of the leading causes of fibrosis in various diseases.
Book ChapterDOI
Role of Airway Smooth Muscle Cells in Asthma Pathology
TL;DR: The role of ASM in asthma pathological mechanisms including inflammatory reaction, extracellular matrix proteins, cell contraction, cell structure, neuromodulation, airway remodeling, apoptosis, autophagy, miRNA, mitochondria, etc is reviewed.
Journal ArticleDOI
Dynamic evolution of emphysema and airway remodeling in two mouse models of COPD
TL;DR: In this article, the authors observed and compared the evolution of the pathology in two mouse models of COPD induced by cigarette smoke (CS) exposure alone or in combination with lipopolysaccharide (LPS).
Journal ArticleDOI
Characterization of cystic fibrosis airway smooth muscle cell proliferative and contractile activities
Joyce H. Jang,Alice Panariti,Michael O'Sullivan,Melissa Pyrch,Christopher Wong,Anne-Marie Lauzon,James G. Martin +6 more
TL;DR: The combination CFTR corrector and potentiator, VX-809/770, was used to restore proper CFTR function in CF ASM which resulted in a reduction in proliferation and in a normalization of calcium reuptake kinetics.
Journal ArticleDOI
Metabolomics in asthma: A platform for discovery.
TL;DR: In this article, the authors summarized the current status of knowledge in asthma metabolomics at systemic and cellular levels and demonstrated that various metabolic pathways, related to energy metabolism, macromolecular biosynthesis and redox signaling, are differentially modulated in asthma.
References
More filters
Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.