Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
Reads0
Chats0
TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
More filters
Effects of inhaled corticosteroids on clinical and pathological outcomes in COPD - Insights from the GLUCOLD study
TL;DR: ICS increased deposition of several ECM proteins in the airways, which was correlated with improved lung function, suggesting prevention of airway collapse, and withdrawal of ICS induced a relapse in lung function decline and increased airway inflammation in bronchial biopsies and sputum, suggesting that benefits of I CS do not persist after discontinuation.
Journal ArticleDOI
Magnesium isoglycyrrhizinate inhibits airway inflammation in rats with chronic obstructive pulmonary disease.
TL;DR: In this article, the anti-inflammatory effect of Magnesium isoglycyrrhizinate (MgIG) in rats with COPD and investigated the underlying mechanisms were evaluated.
Journal ArticleDOI
Salidroside inhibits platelet-derived growth factor-induced proliferation and migration of airway smooth muscle cells.
TL;DR: The results suggested that salidroside functionally regulated the proliferation, migration, phenotype plasticity, and extracellular matrix deposition in PDGF‐induced ASMCs and the NF‐κB pathway might be implicated in the effects of saldroside on ASMC's induced by PDGF.
Journal ArticleDOI
Airway smooth muscle cells from ovalbumin-sensitized mice show increased proliferative response to TGFβ1 due to upregulation of Smad3 and TGFβRII.
Jianting Shi,Ming Chen,Lihua Ouyang,Linjie Huang,Xiaoling Lin,Wei Zhang,Ruiyun Liang,Zhiqiang Lv,Shanying Liu,Shanping Jiang +9 more
TL;DR: ASMCs isolated from OVA-sensitized mice showed hyper-proliferation upon TGF β1 stimulation, which might have been associated with up-regulated Smad3 and TGFβRII and mediated by ERK1/2 downstream to Smad 3.
Journal ArticleDOI
Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease.
Lei Yang,Xingai Jiao,Jinxiang Wu,Jiping Zhao,Tian Liu,Jianfeng Xu,Xiaohui Ma,Liuzao Cao,Lin Liu,Yahui Liu,Jingyu Chi,Minfang Zou,Shuo Li,Jiawei Xu,Liang Dong +14 more
TL;DR: Treatment with C. sinensis may be a useful approach for COPD therapy, as it significantly ameliorated airway wall thickening and reduced inflammatory cell accumulation and decreased inflammatory cytokine production in rats with COPD.
References
More filters
Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.