Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
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TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
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Journal ArticleDOI
Triptolide inhibits transforming growth factor-β1-induced proliferation and migration of rat airway smooth muscle cells by suppressing nuclear factor-κB but not extracellular signal-regulated kinase 1/2
Ming Chen,Jianting Shi,Zhiqiang Lv,Linjie Huang,Xiaoling Lin,Wei Zhang,Ruiyun Liang,Yi-Qun Li,Shanping Jiang +8 more
TL;DR: Triptolide may function as an inhibitor of asthma airway remodelling by suppressing ASMC proliferation and migration through inactivation of the NF‐κB pathway.
Journal ArticleDOI
Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A.
Hesam Movassagh,Nazanin Tatari,Lianyu Shan,Latifa Koussih,Latifa Koussih,Duaa Al-Subait,Mahdi Khattabi,Naresh Singh Redhu,Naresh Singh Redhu,Michael Roth,Michael Tamm,Jamila Chakir,Abdelilah S. Gounni +12 more
TL;DR: It is reported that semaphorin 3A (Sema3A) receptor, neuropilin 1 (Nrp1), is expressed on human ASM cells isolated from healthy and asthmatic donors and treatment of these cells with exogenous Sema 3A inhibits growth factor-induced proliferation.
Journal ArticleDOI
Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma.
Rodney D. Britt,Michael A. Thompson,Sarah A. Wicher,L. Manlove,A.M. Roesler,Yun Hua Fang,Carolyn M Roos,Leslie A. Smith,Jordan D. Miller,Christina M. Pabelick,Y. S. Prakash +10 more
TL;DR: Novel data indicate that TrkB signaling is a key modulator of AHR and that smooth muscle‐derived BDNF mediates these effects during allergic airway inflammation and that Smooth muscle brain‐derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma.
Journal ArticleDOI
Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma.
Ming Chen,Zhiqiang Lv,Wei Zhang,Linjie Huang,Xiaoling Lin,Jianting Shi,Ruiyun Liang,Shanping Jiang +7 more
TL;DR: Triptolide may inhibit airway goblet cell hyperplasia and Muc5ac expression in asthmatic mice via NF-κB and may be a potential drug for the treatment of patients with severe asthma.
Journal ArticleDOI
Airway smooth muscle enlargement is associated with protease-activated receptor 2/ligand overexpression in patients with difficult-to-control severe asthma.
Michel Aubier,Gabriel Thabut,Fatima Hamidi,Noëlline Guillou,Julien Brard,Marie-Christine Dombret,Keren Borensztajn,Brahim AitIlalne,Isabelle Poirier,Pascale Roland-Nicaise,Camille Taillé,Marina Pretolani +11 more
TL;DR: Increase in ASM mass, possibly involving aberrant expression and activation of PAR-2-mediated pathways, characterizes younger patients with severe asthma with poor asthma control.
References
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Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
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Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
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Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
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Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
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The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.