Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
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TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
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Journal ArticleDOI
Endobronchial Ultrasound Reliably Quantifies Airway Smooth Muscle Remodeling in an Equine Asthma Model.
TL;DR: EBUS reliably allows assessment of asthma-associated ASM remodeling of central airways in a non-invasive way, and Bronchial histology confirmed the findings.
Journal ArticleDOI
Airway and Lung Remodelling in Chronic Pulmonary Obstructive Disease: A Role for Muscarinic Receptor Antagonists?
TL;DR: The role of muscarinic receptors in lung tissue remodelling as it has been reported in the human lung as well as their supportive role for other remodelling driving factors is investigated.
Journal ArticleDOI
TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/β-catenin signaling
Pierre-Joseph Royer,K. Henrio,Mallory Pain,Jennifer Loy,A. Roux,Adrien Tissot,Philippe Lacoste,Christophe Pison,Sophie Brouard,Antoine Magnan +9 more
TL;DR: Mechanical analyses suggest the secretion of Wnt ligands by AEC along with a degradation of the cellular junctions after poly(I:C) exposure, leading to the release of β-catenin from the cell membrane and stimulation of the Wnt/β- catenin pathway.
Journal ArticleDOI
Lysophosphatidylcholines inhibit human eosinophil activation and suppress eosinophil migration in vivo
Eva Knuplez,Sanja Curcic,Anna Theiler,Thomas Bärnthaler,Athina Trakaki,Markus Trieb,Michael Holzer,Akos Heinemann,Robert Zimmermann,Eva M. Sturm,Gunther Marsche +10 more
TL;DR: It is demonstrated in a mouse model of allergic cell recruitment, that LPC treatment markedly reduces immune cell infiltration into the lungs and suggest a strong modulatory activity of LPCs in the regulation of eosinophilic inflammation in vitro and in vivo.
Journal ArticleDOI
The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics.
Yahui Liu,Tian Liu,Jinxiang Wu,Tao Li,Xingai Jiao,Haiqing Zhang,Jiping Zhao,Junfei Wang,Lin Liu,Liuzhao Cao,Shuo Li,Jiawei Xu,Jianfeng Xu,Xiaohui Ma,Lei Yang,Liang Dong +15 more
TL;DR: FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM, and may contribute to airway remodeling in astHmatics.
References
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Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
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Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.