Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
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TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
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A novel, noninvasive assay shows that distal airway oxygen tension is low in cystic fibrosis, but not in primary ciliary dyskinesia.
TL;DR: Using a novel, fast‐response sensor, a noninvasive procedure is developed to measure pO2 in distal human airways and hypothesized that distal pO 2 would be low in cystic fibrosis (CF) airways.
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Inflammation resolution in environmental pulmonary health and morbidity.
TL;DR: In this paper , the role of air pollution in COPD onset and exacerbated pathogenesis has been well documented, and multi-antioxidant enzymes take immediate action including peroxiredoxins.
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Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia
TL;DR: In this paper , the authors focus on cells in the epithelium which lines two regions of the human respiratory tract and the male genital ducts to delineate the shared, differentiated functions of the different cell populations.
Journal ArticleDOI
Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease
Yuan Zhan,Jinkun Chen,Jixing Wu,Yiya Gu,Qian Huang,Z. Deng,Shanshan Chen,Xiaojie Wu,Yongman Lv,Zhilin Zeng,Jungang Xie +10 more
TL;DR: In this article , the role of HE4 in COPD was investigated using immunohistochemical staining, qPCR, western blot, CCK8 assay or 5-ethynyl-2'-deoxyuridine (EdU) staining.
Journal ArticleDOI
Recombinant Pyrin Domain Protein Attenuates Airway Inflammation and Alleviates Epithelial-Mesenchymal Transition by Inhibiting Crosstalk Between TGFβ1 and Notch1 Signaling in Chronic Asthmatic Mice.
Zhiguang Wang,Liangchang Li,Chongyang Wang,Yihua Piao,Jingzhi Jiang,Li Li,Guanghai Yan,Hongmei Piao +7 more
TL;DR: RPYD reduces airway inflammation, improves airway remodeling and reduces EMT in chronic asthmatic mice by inhibiting the crosstalk between TGFβ1/smad3 and Jagged1/Notch1 signaling pathways.
References
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Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
The relations between structural changes in small airways and pulmonary-function tests.
Manuel G. Cosio,H. Ghezzo,James C. Hogg,R. Corbin,M. Loveland,James A. Dosman,Peter T. Macklem +6 more
TL;DR: Pulmonary-function tests showed abnormalities at a time when the pathologic changes were still potentially reversible and when other tests were not appreciably changed, and increase in disease in small airways correlated with deterioration in lung function.