Journal ArticleDOI
Mechanisms of Airway Remodeling
Nobuaki Hirota,James G. Martin +1 more
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TLDR
Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.About:
This article is published in Chest.The article was published on 2013-09-01. It has received 260 citations till now. The article focuses on the topics: Airway.read more
Citations
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Journal ArticleDOI
TGF-β1 Signaling and Tissue Fibrosis.
TL;DR: The current understanding of the core functions of TGF-β1 in promoting collagen accumulation, parallel pathways that promote physiological repair, and pathological triggers that tip the balance toward progressive fibrosis are examined.
Journal ArticleDOI
Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.
Coen Wiegman,Charalambos Michaeloudes,Gulammehdi Haji,Priyanka Narang,Colin Clarke,Kirsty E. Russell,Wuping Bao,Stelios Pavlidis,Peter J. Barnes,Justin Kanerva,Anton Bittner,Navin Rao,Michael P. Murphy,Paul Kirkham,Kian Fan Chung,Ian M. Adcock,Christopher E. Brightling,Donna E. Davies,Donna K. Finch,Andrew J. Fisher,Alasdair Gaw,Alan J. Knox,Ruth J. Mayer,Michael I. Polkey,Michael Salmon,David Singh +25 more
TL;DR: Mitochondrial dysfunction in patients with COPD is associated with excessive mitochondrial ROS levels, which contribute to enhanced inflammation and cell hyperproliferation.
Journal ArticleDOI
Neutrophilic Inflammation in Asthma and Association with Disease Severity.
Anuradha Ray,Jay K. Kolls +1 more
TL;DR: Current knowledge of the role of neutrophils in asthma is reviewed and future avenues of research in this field are highlighted to help delineate different subtypes of asthma.
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Cellular and molecular mechanisms of asthma and COPD.
TL;DR: The inflammatory and cellular mechanisms of asthma and COPD are compared and the differences in inflammatory cells and profile of inflammatory mediators are highlighted to better understand the underlying cellular and molecular mechanisms in order to develop new treatments in areas of unmet need.
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Airway remodeling in asthma: what really matters.
TL;DR: This review will address a few major aspects: what are reliable quantitative approaches to assess airway remodeling, and are there any indications supporting the notion that airways remodeling can occur as a primary event, i.e., before any inflammatory process was initiated?
References
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Journal ArticleDOI
Effects of a Low-Molecular-Weight CCR-3 Antagonist on Chronic Experimental Asthma
Michael Wegmann,Rolf Göggel,Sarper Sel,Serdar Sel,Klaus J. Erb,Frank Kalkbrenner,Harald Renz,Holger Garn +7 more
TL;DR: It is demonstrated that antagonism of CCR3 reduces eosinophil numbers, which is accompanied by diminution of asthma pathology in a mouse model of established chronic experimental asthma, indicating a new approach toward a promising asthma therapy.
Journal ArticleDOI
TH17 Cytokines Induce Human Airway Smooth Muscle Cell Migration
Ying Chang,Laila Al-Alwan,Paul-André Risse,Lucie Roussel,Simon Rousseau,Andrew J. Halayko,James G. Martin,Qutayba Hamid,David H. Eidelman +8 more
TL;DR: The possibility that T(H)17-associated cytokines promote human ASMC migration in vivo is raised and an important new mechanism for the promotion of airway remodeling in asthma is suggested.
Journal ArticleDOI
Corticosteroids and Antigen Avoidance Decrease Airway Smooth Muscle Mass in an Equine Asthma Model
Mathilde Leclere,Anouk Lavoie-Lamoureux,Philippe Joubert,Fabien Relave,Emilie Lanctot Setlakwe,Guy Beauchamp,Christian Couture,James G. Martin,Jean-Pierre Lavoie +8 more
TL;DR: Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance.
Journal ArticleDOI
Cartilaginous airway wall dimensions and airway resistance in cystic fibrosis lungs
Harm A.W.M. Tiddens,Laurens P. Koopman,R.K. Lambert,W.m Elliott,Wim C. J. Hop,T.w Van Der Mark,W.J. de Boer,J. C. De Jongste +7 more
TL;DR: The sensitivity and maximal plateau resistance of the computed dose/response curves were substantially increased in the CF patients compared to COPD patients and probably contribute to the severe airflow obstruction, and to increased bronchial responsiveness, in these patients.
Journal ArticleDOI
PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1.
Marina C. Simeone-Penney,Mariano Severgnini,Lilliana Rozo,Satoe Takahashi,Brent H. Cochran,Amy Simon +5 more
TL;DR: A novel mitogenic signaling pathway in airway smooth muscle cells leading from PDGF to Rac1 and STAT3 and subsequent cell cycle gene regulation is defined, which may prove to be a novel therapeutic approach for patients with severe asthma and significant airway wall remodeling.