Mechanisms regulating zygotic genome activation.
TLDR
The maternal-to-zygotic transition (MZT) is the process by which the transcriptionally silent embryonic genome is gradually activated, and recent work indicates that transcriptional activators have an important role.Abstract:
Following fertilization, the two specified gametes must unite to create an entirely new organism. The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a totipotent state. Gradually, the genome is activated through a process known as the maternal-to-zygotic transition, which enables zygotic gene products to replace the maternal supply that initiated development. This essential transition has been broadly characterized through decades of research in several model organisms. However, we still lack a full mechanistic understanding of how genome activation is executed and how this activation relates to the reprogramming of the zygotic chromatin architecture. Recent work highlights the central role of transcriptional activators and suggests that these factors may coordinate transcriptional activation with other developmental changes.read more
Citations
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Journal ArticleDOI
The maternal-to-zygotic transition revisited.
TL;DR: Current understanding of the mechanisms that underlie handover of developmental control to the zygotic genome during the maternal-to-zygotic transition is reviewed.
Posted ContentDOI
Beyond accessibility: ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
Mette Bentsen,Philipp Goymann,Hendrik Schultheis,Anastasiia Petrova,Kathrin Klee,Annika Fust,Jens Preussner,Carsten Kuenne,Thomas Braun,Johnny Kim,Mario Looso +10 more
TL;DR: ToBIAS is presented, a comprehensive, accurate, and fast footprinting framework enabling genome-wide investigation of TF binding dynamics for hundreds of TFs simultaneously, and illustrated how to unveil complex TF dynamics during zygotic genome activation (ZGA) in both humans and mice.
Journal ArticleDOI
Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.
Shun Hang Chan,Yin Tang,Liyun Miao,Hiba Darwich-Codore,Charles E. Vejnar,Jean-Denis Beaudoin,Damir Musaev,Juan P. Fernandez,Maria D.J. Benitez,Ariel A. Bazzini,Ariel A. Bazzini,Miguel A. Moreno-Mateos,Antonio J. Giraldez +12 more
TL;DR: It is concluded that P300 and Brd4 are sufficient to trigger genome-wide transcriptional competency by regulating histone acetylation on the first zygotic genes in zebrafish, which is critical for initiatingZygotic development and developmental reprogramming.
Journal ArticleDOI
Insights into epigenetic patterns in mammalian early embryos
TL;DR: The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals, including DNA methylation, histone modifications, chromatin accessibility and 3D chromatin organization.
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