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Medicinal mushroom: boon for therapeutic applications

TLDR
The present review focuses on the comprehensive account of the medicinal properties of various medicinal mushrooms, which will further help the researchers to understand the metabolites and find other metabolites from the mushrooms which can be used for the potential development of the drugs to treat various life-threatening diseases.
Abstract
Medicinal mushrooms are higher fungi with additional nutraceutical attributes having low fat content and a trans-isomer of unsaturated fatty acids along with high fibre content, triterpenes, phenolic compounds, sterols, eritadenine and chitosan. They are considered as the unmatched source of healthy foods and drugs. They have outstanding attractive taste, aroma and nutritional value, so are considered as functional food, which means they are beneficial to the body not only in terms of nutrition but also for improved health. Medicinal mushrooms and their extract have a large number of bioactive components called secondary metabolites. The presence of polysaccharide β-glucans or polysaccharide–protein complexes content in mushroom extract have great therapeutic applications in human health as they possess many properties such as anti-diabetic, anti-cancerous, anti-obesity, immunomodulatory, hypocholesteremia, hepatoprotective nature along with anti-aging. The present review focuses on the comprehensive account of the medicinal properties of various medicinal mushrooms. This will further help the researchers to understand the metabolites and find other metabolites as well from the mushrooms which can be used for the potential development of the drugs to treat various life-threatening diseases.

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Journal ArticleDOI

The biology of ergothioneine, an antioxidant nutraceutical.

TL;DR: Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems, and it may have value as a nutraceutical and antioxidant more generally.
Journal ArticleDOI

Current Prospects of Nutraceuticals: A Review.

TL;DR: An overview of various bioactive ingredients which act as nutraceuticals (carbohydrates, lipids, edible flowers, alkaloids, medicinal plants, etc.) and their role in health benefits has been discussed and further application of nutr pharmaceuticals in various diseases prevention has been also discussed.
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Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma.

TL;DR: The molecular mechanisms that come from other than HBV endemic places which can be innovative approaches to treat HCC are outlined.
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Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products.

TL;DR: The current status of clinical studies on immunomodulatory activities of mushrooms and mushroom products are reviewed and the approaches that have been used in the development and application of bioactive compounds extracted from mushrooms are described.
Journal ArticleDOI

Edible Mushrooms as Functional Ingredients for Development of Healthier and More Sustainable Muscle Foods: A Flexitarian Approach.

TL;DR: In this article, the effects of functional ingredients of mushrooms in improving the quality and sensory attributes of nutritionally superior and next-generation healthier muscle food products are also highlighted in this paper.
References
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Journal ArticleDOI

Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis.

TL;DR: It is shown that vulpinic acid derived from a mushroom, Pulveroboletus ravenelii controls the cell fate of mesenchymal stem cells and preadipocytes by inducing the acetylation of histone H3 and α-tubulin, respectively.
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Effect of edible mushroom (Pleurotus ostreatus) on type-2 diabetics

TL;DR: Mushroom was found to have significant effect in reducing blood glucose, T-chol, TG and LDL and no impaired function was observed for liver, kidney and hemopoeitic tissue in taking mushroom for 360 days of the study period.
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Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201

TL;DR: Results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.

Ganoderma lucidum (Fr.) P. Karst occurring in South India attenuates gastric ulceration in rats

TL;DR: The findings suggest the potential therapeutic use of G. lucidum as an effective non-toxic antiulcer agent and the antiulcers property of the mushroom might be due to its profound free radical scavenging activity.
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Pleurotus florida Aqueous Extracts and Powder Influence Lipid Profileand Suppress Weight Gain in Rats Fed High Cholesterol Diet

TL;DR: Results show that P. florida extracts like powders possess antihypercholesterolemic effects and prevent weight gain, thus reducing the risk for cardiovascular diseases and Mechanisms for these effects are suggested.
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