Journal ArticleDOI
MEG3: an Oncogenic Long Non-coding RNA in Different Cancers.
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TLDR
Biological function of MEG3 to repress tumor through regulating the major tumor suppressor genes p53 and Rb, inhibiting angiogenesis-related factor, or controlling miRNAs is highlighted.Abstract:
Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Several lncRNAs can be classified into oncogenes and tumor suppressor genes depending on their function in cancer. A maternally expressed gene 3 (MEG3) gene transcripts a 1.6 kb lncRNA whose act as an antitumor component in different cancer cells, such as breast, liver, glioma, colorectal, cervical, gastric, lung, ovarian and osteosarcoma cancer cells. The present review highlights biological function of MEG3 to repress tumor through regulating the major tumor suppressor genes p53 and Rb, inhibiting angiogenesis-related factor, or controlling miRNAs. On the other hand, previous studies have also suggested that MEG3 mediates epithelial-mesenchymal transition (EMT). However, deregulation of MEG3 is associated with the development and progression of cancer, suggesting that MEG3 may function as a potential biomarker and therapeutic target for human cancers.read more
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Long Non-Coding RNA in the Pathogenesis of Cancers.
TL;DR: The latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma are discussed.
Journal ArticleDOI
Mechanisms of lncRNA/microRNA interactions in angiogenesis.
TL;DR: A better understanding of the mechanisms of lncRNA/microRNA interactions in angiogenesis may provide helpful insights and shed new light on areas of research for identifying diagnostic markers and therapeutic approaches for treatingAngiogenesis-related diseases.
Journal ArticleDOI
The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment.
TL;DR: The potential role of HOTAIR overexpression on different processes of breast cancer development is summarized and the relationship of this lncRNA with different therapeutic approaches is discussed.
Journal ArticleDOI
Exosomal Long Non-Coding RNAs in Lung Diseases.
Christophe Poulet,Makon-Sébastien Njock,Catherine Moermans,Edouard Louis,Renaud Louis,Michel Malaise,Julien Guiot +6 more
TL;DR: The need for additional studies describing the lncRNA mechanisms of action and confirming their potential as biomarkers, as well as their involvement in resistance to treatment, especially in non-cancerous lung diseases is concluded.
References
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