Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TLDR
Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.Abstract:
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered G αi- and integrin-dependent arrest and chemotaxis of monocytes and T cells, rapid integrin activation and calcium influx through CXCR2 or CXCR4. MIF competed with cognate ligands for CXCR4 and CXCR2 binding, and directly bound to CXCR2. CXCR2 and CD74 formed a receptor complex, and monocyte arrest elicited by MIF in inflamed or atherosclerotic arteries involved both CXCR2 and CD74. In vivo, Mif deficiency impaired monocyte adhesion to the arterial wall in atherosclerosis-prone mice, and MIF-induced leukocyte recruitment required Il8rb (which encodes Cxcr2). Blockade of Mif but not of canonical ligands of Cxcr2 or Cxcr4 in mice with advanced atherosclerosis led to plaque regression and reduced monocyte and T-cell content in plaques. By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition. © 2007 Nature Publishing Group.read more
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Book ChapterDOI
Platelet Chemokines in New Modes of Action
TL;DR: The recently discovered multifaceted aspects of platelet chemokines as emphasised in this chapter encourages further experimental and clinical investigations in this expansive but still largely uncharted area of research in platelet biology.
Journal ArticleDOI
A secreted MIF homologue from Trichinella spiralis binds to and interacts with host monocytes.
TL;DR: In this paper , the authors investigated the role of Trichinella spiralis MIF (TsMIF) in the development of muscle larvae and found that the secreted TsMIF plays an important role in the interaction between TSS and its host and could be a potential drug or vaccine target molecule against TSS infection.
Journal ArticleDOI
MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment
Laura Garcia-Gerique,Marta Garcia,Alícia Garrido-Garcia,Soledad Gomez-Gonzalez,Montserrat Torrebadell,Estela Prada,Guillem Pascual-Pasto,Oscar Muñoz,Sara Perez-Jaume,Isadora Lemos,Noelia Salvador,Monica Vila-Ubach,Ana Doncel-Requena,Mariona Suñol,Angel M. Carcaboso,Jaume Mora,Cinzia Lavarino +16 more
TL;DR: In this paper , the authors explored biological mechanisms that play a critical role in NB cell survival and progression in the bone marrow and investigated potential therapeutic targets for patients with metastatic neuroblastoma.
Journal ArticleDOI
Single‐Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma
Yongxu Jia,Baifeng Zhang,Chunyang Zhang,Dora L.W. Kwong,Zhi Wei Chang,Shan-Shan Li,Ze-Kang Wang,Huiqiong Han,Jin Li,Yali Zhong,Xinbing Sui,Li Fu,Xinyuan Guan,Yan Ru Qin +13 more
TL;DR: In this article , the transcriptomes of 85 263 single cells were analyzed from four esophageal squamous carcinoma (ESCC) patients with lymph node metastases, and it was observed that the metastatic microenvironment undergoes the emergence or expansion of interferon induced IFIT3+ T, B cells, and immunosuppressive cells such as APOC1+APOE+ macrophages and myofibroblasts with highly expression of immunoglobulin genes (IGKC) and extracellular matrix component and matrix metallopeptidase genes.
Regulation of neutrophil homeostasis by chemokines signaling through the CXCR2 and CXCR4 receptors
TL;DR: CXCR4 is a key regulator of neutrophil release from the bone 63 marrow under basal and stress granulopoiesis conditions and CXCR2 and CxCR4 antagonistically regulate neutrophIL 99 trafficking from theBone marrow.
References
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