Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TLDR
Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.Abstract:
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered G αi- and integrin-dependent arrest and chemotaxis of monocytes and T cells, rapid integrin activation and calcium influx through CXCR2 or CXCR4. MIF competed with cognate ligands for CXCR4 and CXCR2 binding, and directly bound to CXCR2. CXCR2 and CD74 formed a receptor complex, and monocyte arrest elicited by MIF in inflamed or atherosclerotic arteries involved both CXCR2 and CD74. In vivo, Mif deficiency impaired monocyte adhesion to the arterial wall in atherosclerosis-prone mice, and MIF-induced leukocyte recruitment required Il8rb (which encodes Cxcr2). Blockade of Mif but not of canonical ligands of Cxcr2 or Cxcr4 in mice with advanced atherosclerosis led to plaque regression and reduced monocyte and T-cell content in plaques. By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition. © 2007 Nature Publishing Group.read more
Citations
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Journal ArticleDOI
The duality of chemokines in heart failure.
Andrew A. Jarrah,Sima T. Tarzami +1 more
TL;DR: By regulating the movement of pro-inflammatory cell types to sites of injury, the authors see now how the myocardium responds to stress.
Journal ArticleDOI
The use of flow cytometry to assess a novel drug efficacy in multiple sclerosis
Gil Benedek,Roberto Meza-Romero,Roberto Meza-Romero,Dennis Bourdette,Dennis Bourdette,Arthur A. Vandenbark +5 more
TL;DR: The cell surface expression level of CD74, the MHCclass II invariant chain, is a potential disease biomarker that could be monitored by FACS analysis in order to assess disease progression and the clinical efficacy of partial MHC class II constructs in treating MS.
Journal ArticleDOI
Evaluating macrophage migration inhibitory factor 1 expression as a prognostic biomarker in colon cancer.
TL;DR: Although migration inhibitory factor 1 mRNA expression levels were related to severity of disease and lymph node analysis revealed that colon cancer patients with high levels had a shorter survival time after surgery than those with low levels, the difference was small and probably not useful in clinical practice.
Journal ArticleDOI
Macrophage migration inhibitory factor contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation.
TL;DR: Plasma levels of circulating MIF were significantly higher in AAV patients with active disease compared with those in remission and healthy controls and Interleukin-8, IL-6 and IL-23 were involved in ANCA-induced activation of MIF-primed neutrophils.
Journal ArticleDOI
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India.
Anshuman Mishra,Pandarisamy Sundaravadivel,Sunil Kumar Tripathi,Rajan Kumar Jha,Jaydeep Badrukhiya,Nipa Basak,Nipa Basak,Isha Anerao,Akshay Sharma,Ajayi Ebenezer Idowu,Ajayi Ebenezer Idowu,Abhishek Mishra,Sonika Pandey,Umesh Kumar,Sakshi Singh,Sheikh Nizamuddin,Nitin Tupperwar,Aditya Nath Jha,Kumarasamy Thangaraj +18 more
TL;DR: It is concluded that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians.
References
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